Exposure to Drinking Water Trihalomethanes and Their Association with Low Birth Weight and Small for Gestational Age in Genetically Susceptible Women
Asta Danileviciute,Regina Grazuleviciene,Jone Vencloviene,Algimantas Paulauskas,Mark J. Nieuwenhuijsen +4 more
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TLDR
It is suggested that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.Abstract:
Little is known about genetic susceptibility to individual trihalomethanes (THM) in relation to adverse pregnancy outcomes. We conducted a nested case-control study of 682 pregnant women in Kaunas (Lithuania) and, using individual information on drinking water, ingestion, showering and bathing, and uptake factors of THMs in blood, estimated an internal THM dose. We used logistic regression to evaluate the relationship between internal THM dose, birth outcomes and individual and joint (modifying) effects of metabolic gene polymorphisms. THM exposure during entire pregnancy and specific trimesters slightly increased low birth weight (LBW) risk. When considering both THM exposure and maternal genotypes, the largest associations were found for third trimester among total THM (TTHM) and chloroform-exposed women with the GSTM1–0 genotype (OR: 4.37; 95% CI: 1.36–14.08 and OR: 5.06; 95% CI: 1.50–17.05, respectively). A test of interaction between internal THM dose and GSTM1–0 genotype suggested a modifying effect of exposure to chloroform and bromodichloromethane on LBW risk. However, the effect on small for gestational age (SGA) was not statistically significant. These data suggest that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.read more
Citations
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Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes.
TL;DR: Newborns genetic variations of CYP2E1 rs2031920 may modify the impacts of prenatal BrTHM exposure on birth weight, and this finding needs to be further confirmed.
Journal ArticleDOI
Postnatal weight growth and trihalomethane exposure during pregnancy.
Jérémie Botton,Manolis Kogevinas,Esther Gracia-Lavedan,Evridiki Patelarou,Theano Roumeliotaki,Carmen Iñiguez,Loreto Santa Marina,Jesús Ibarluzea,Ferran Ballester,Michelle Ann Mendez,Leda Chatzi,Jordi Sunyer,Cristina M. Villanueva +12 more
TL;DR: No consistent evidence of an association between THM exposure during pregnancy and postnatal growth was observed and the novelty of the hypothesis and the negative trend observed in the region with the highest levels warrants the replication in future studies.
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Limited representation of drinking-water contaminants in pregnancy-birth cohorts.
TL;DR: It appears that chemical-based water contamination and corresponding human exposures represent a largely underappreciated niche of exposure science pertaining to pregnant mother and children's health in PBC.
Method to assess component contribution to toxicity of complex mixtures: Assessment of puberty acquisition in rats exposed to disinfection byproducts
Shahid Parvez,Glenn E. Rice,Linda K. Teuschler,Jane Ellen Simmons,Thomas F. Speth,Susan D. Richardson,Richard J. Miltner,E. Sidney Hunter,Jonathan G. Pressman,Lillian F. Strader,Gary R. Klinefelter,Jerome M. Goldman,Michael G. Narotsky +12 more
TL;DR: The delay in puberty acquisition observed in the WM-treated female rats could not be distinguished from delays predicted by the DM regression model, suggesting that the nine regulated DBPs in the DM might account for much of the delay observed inThe WM.
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Prenatal exposure to drinking-water chlorination by-products, cytochrome P450 gene polymorphisms and small-for-gestational-age neonates.
TL;DR: There is some evidence, albeit weak, of a potential effect modification of the association between CBPs and SGA by SNPs in CYP17A1 gene, but further studies are needed to validate these observations.
References
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John D. Hayes,Richard C. Strange +1 more
TL;DR: Two supergene families encode proteins with glutathione S-transferase (GST) activity that detoxify a variety of electrophilic compounds, including oxidized lipid, DNA and catechol products generated by reactive oxygen species-induced damage to intracellular molecules.
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Xiaobin Wang,Barry Zuckerman,Colleen Pearson,Gary Kaufman,Changzhong Chen,Guoying Wang,Tianhua Niu,Paul H. Wise,Howard Bauchner,Xiping Xu +9 more
TL;DR: In this study, maternal CYP1A1 and GSTT1 genotypes modified the association between maternal cigarette smoking and infant birth weight, suggesting an interaction between metabolic genes and cigarette smoking.
Journal ArticleDOI
Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review
TL;DR: To identify the specific components that may be of aetiological concern and hence to fit the most appropriate exposure model with which to investigate human exposure to chlorinated DBPs, further detailed toxicological assessments of the mixture of byproducts commonly found in drinking water are also needed.
Journal ArticleDOI
Public Drinking Water Contamination and Birth Outcomes
Frank J. Bove,Mark C. Fulcomer,Judith B. Klotz,Jorge Esmart,Ellen M. Dufficy,Jonathan E. Savrin +5 more
TL;DR: The effects of public drinking water contamination on birth outcomes were evaluated in an area of northern New Jersey and it cannot resolve whether the drinking water contaminants caused the adverse birth outcomes; therefore, these findings should be followed up utilizing available drinkingWater contamination databases.