Exposure to Drinking Water Trihalomethanes and Their Association with Low Birth Weight and Small for Gestational Age in Genetically Susceptible Women
Asta Danileviciute,Regina Grazuleviciene,Jone Vencloviene,Algimantas Paulauskas,Mark J. Nieuwenhuijsen +4 more
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TLDR
It is suggested that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.Abstract:
Little is known about genetic susceptibility to individual trihalomethanes (THM) in relation to adverse pregnancy outcomes. We conducted a nested case-control study of 682 pregnant women in Kaunas (Lithuania) and, using individual information on drinking water, ingestion, showering and bathing, and uptake factors of THMs in blood, estimated an internal THM dose. We used logistic regression to evaluate the relationship between internal THM dose, birth outcomes and individual and joint (modifying) effects of metabolic gene polymorphisms. THM exposure during entire pregnancy and specific trimesters slightly increased low birth weight (LBW) risk. When considering both THM exposure and maternal genotypes, the largest associations were found for third trimester among total THM (TTHM) and chloroform-exposed women with the GSTM1–0 genotype (OR: 4.37; 95% CI: 1.36–14.08 and OR: 5.06; 95% CI: 1.50–17.05, respectively). A test of interaction between internal THM dose and GSTM1–0 genotype suggested a modifying effect of exposure to chloroform and bromodichloromethane on LBW risk. However, the effect on small for gestational age (SGA) was not statistically significant. These data suggest that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.read more
Citations
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Application of Classification Trees for Predicting Disinfection By-Product Formation Targets from Source Water Characteristics
TL;DR: In this article, classification trees were used to predict violation of or compliance with four threshold values that have regulatory and operational significance, namely, the total trihalomethanes (TTHMs) maximum contaminant level (MCL), 80% of the TTHMs MCL (64μg/L), a bromine incorporat...
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Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study.
TL;DR: Chlorination by-products exposure via drinking water was associated with increased risk of SGA in areas with hypochlorite treatment, and no clear associations were observed for pre term delivery and very preterm delivery.
Journal ArticleDOI
Impact of chloroform exposures on reproductive and developmental outcomes: A systematic review of the scientific literature.
Amy Lavin Williams,Christopher A. Bates,Nelson D. Pace,Megan J. Leonhard,Ellen T. Chang,John M. DeSesso,John M. DeSesso +6 more
TL;DR: This work assessed the animal and epidemiological data to determine if chloroform exposure causes developmental and/or reproductive toxicity in animals and in humans.
Journal ArticleDOI
Development and application of a human PBPK model for bromodichloromethane to investigate the impacts of multi-route exposure.
TL;DR: Large contributions of dermal and inhalation exposure routes to the internal dose of parent chemical reaching the systemic circulation, which could be transformed to mutagenic metabolites in extrahepatic target tissues are demonstrated.
Journal ArticleDOI
Disinfection by-products exposure and intra-uterine growth restriction: Do genetic polymorphisms of CYP2E1or deletion of GSTM1 or GSTT1 modify the association?
Patrick Levallois,Yves Giguère,Molière Nguile-Makao,Manuel J. Rodriguez,Céline Campagna,Robert Tardif,Alexandre Bureau +6 more
TL;DR: Examining interactions between trihalomethanes (THM) or haloacetic acids (HAA) exposure and genetic polymorphisms on small for gestational age (SGA) neonates by investigating single nucleotide polymorphisms (SNPs) in CYP2E1 gene and GSTM1 and GSTT1 deletions in mothers-children pairs finds interactions were not replicated.
References
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Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.
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John D. Hayes,Richard C. Strange +1 more
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Xiaobin Wang,Barry Zuckerman,Colleen Pearson,Gary Kaufman,Changzhong Chen,Guoying Wang,Tianhua Niu,Paul H. Wise,Howard Bauchner,Xiping Xu +9 more
TL;DR: In this study, maternal CYP1A1 and GSTT1 genotypes modified the association between maternal cigarette smoking and infant birth weight, suggesting an interaction between metabolic genes and cigarette smoking.
Journal ArticleDOI
Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review
TL;DR: To identify the specific components that may be of aetiological concern and hence to fit the most appropriate exposure model with which to investigate human exposure to chlorinated DBPs, further detailed toxicological assessments of the mixture of byproducts commonly found in drinking water are also needed.
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Public Drinking Water Contamination and Birth Outcomes
Frank J. Bove,Mark C. Fulcomer,Judith B. Klotz,Jorge Esmart,Ellen M. Dufficy,Jonathan E. Savrin +5 more
TL;DR: The effects of public drinking water contamination on birth outcomes were evaluated in an area of northern New Jersey and it cannot resolve whether the drinking water contaminants caused the adverse birth outcomes; therefore, these findings should be followed up utilizing available drinkingWater contamination databases.