Journal ArticleDOI
Facile and Efficient Guanylation of Amines Using Thioureas and Mukaiyama's Reagent
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This article is published in Journal of Organic Chemistry.The article was published on 1997-03-07. It has received 157 citations till now. The article focuses on the topics: Reagent.read more
Citations
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Diprotected Triflylguanidines: A New Class of Guanidinylation Reagents
Journal ArticleDOI
Natural guanidine derivatives
TL;DR: The literature on guanidine-bearing natural products is reviewed, with emphasis on occurrence, isolation, structure determination, biosynthesis, synthesis and biological activities, with 365 references.
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Guanidines: from classical approaches to efficient catalytic syntheses
TL;DR: This review focuses on the metal-mediated catalytic addition of amines to carbodiimides as an atom-economical alternative to the classical synthesis.
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Triurethane-Protected Guanidines and Triflyldiurethane-Protected Guanidines: New Reagents for Guanidinylation Reactions
TL;DR: The triflyldiurethane-protected guanidine 3 was utilized to guanidinylate primary and secondary amines under mild conditions with high yield in both solution and on solid phase.
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Derivatization procedures to facilitate de novo sequencing of lysine-terminated tryptic peptides using postsource decay matrix-assisted laser desorption/ionization mass spectrometry.
TL;DR: The combined reactions convert lysine-terminated tryptic peptides into modified peptides that are suitable for de novo sequencing by postsource decay matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.
References
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Journal ArticleDOI
Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.
TL;DR: A rapid and sensitive method for the quantitative determination of free amino groups during solid-phase peptide synthesis has been developed and is useful for measuring the total number of peptide chains on the resin and, especially, for monitoring the progress of the coupling reaction.
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Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.
TL;DR: In this article, a trialkoxy-diphenyl-methylester and amide linkage for solid-phase peptide synthesis with Fmoc strategy is described, which can be smoothly cleaved with weak acid, resulting in fragments with intact side-chain protection.
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1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis
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Improved method for the preparation of guanidines
Kyoung S. Kim,Ligang Qian +1 more
TL;DR: In this paper, the use of N,N′-di-(tert-butoxycarbonyl)thiourea 1 in the presence of mercuric chloride provides a very efficient method for the bis-Boc protected guanidine formation of the amino compounds which are highly deactivated either sterically or electronically.