Journal ArticleDOI
Facts and fallacies of blood pressure control in recent trials: implications in the management of patients with hypertension.
Alberto Zanchetti,Giuseppe Mancia,Henry R. Black,Suzanne Oparil,Bernard Waeber,Roland E. Schmieder,George L. Bakris,Franz H. Messerli,Sverre E. Kjeldsen,Luis M. Ruilope +9 more
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It is concluded that their complex design precludes a simple interpretation, that several important questions remain unanswered and that direct evidence – particularly in support of lowering systolic BP below 140 or 130 mmHg – is urgently needed.Abstract:
A large body of clinical trial data indicates that a given difference in blood pressure (BP), as measured in the clinic, results in a given difference in outcome. This correlation underpins current US and European guidelines for the management of hypertension. However, findings from recent comparative trials may appear inconsistent with a fixed relationship between BP lowering and outcome benefit, at least at all BP ranges, at all levels of total cardiovascular risk and with all drug combinations. We review the findings of six of these recent trials and conclude that their complex design precludes a simple interpretation, that several important questions remain unanswered and that direct evidence - particularly in support of lowering systolic BP below 140 or 130 mmHg - is urgently needed.read more
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Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document.
Giuseppe Mancia,Stéphane Laurent,Enrico Agabiti-Rosei,Ettore Ambrosioni,Michel Burnier,Mark J. Caulfield,Renata Cifkova,Denis Clement,Antonio Coca,Anna F. Dominiczak,Serap Erdine,Robert Fagard,Csaba Farsang,Guido Grassi,Hermann Haller,Anthony M. Heagerty,Sverre E. Kjeldsen,Wolfgang Kiowski,Jean Michel Mallion,Athanasios J. Manolis,Krzysztof Narkiewicz,Peter M. Nilsson,Michael H. Olsen,Karl H. Rahn,Josep Redon,Jose L. Rodicio,Luis M. Ruilope,Roland E. Schmieder,Harry A.J. Struijker-Boudier,Pieter A. Van Zwieten,Margus Viigimaa,Alberto Zanchetti +31 more
TL;DR: The objective of this study was to establish a baseline for the design of a systematic literature review of this type of treatment for high blood pressure using a simple, straightforward, and scalable procedure.
Book
Reappraisal of European guidelines on hypertension management:: A European Society of Hypertension Task Force document
Giuseppe Mancia,Stéphane Laurent,Enrico Agabiti-Rosei,Ettore Ambrosioni,Michel Burnier,Mark J. Caulfield,Renata Cifkova,Denis Clement,Antonio Coca,Anna F. Dominiczak,Serap Erdine,Robert Fagard,Csaba Farsang,Guido Grassi,Hermann Haller,Anthony M. Heagerty,Sverre E. Kjeldsen,Wolfgang Kiowski,Jean Michel Mallion,Athanasios J. Manolis,Krzysztof Narkiewicz,Peter M. Nilsson,Michael H. Olsen,Karl H. Rahn,Josep Redon,Jose L. Rodicio,Luis M. Ruilope,Roland E. Schmieder,Harry A.J. Struijker-Boudier,Pieter A. Van Zwieten,Margus Viigimaa,Alberto Zanchetti +31 more
TL;DR: This article estimated glomerular filtration rate of the human glomerus and showed that the estimated rate can be improved by using the enzyme GFR-BPBP-DBPDBPdiastolic blood pressure
Journal ArticleDOI
Factors Influencing the Decline in Stroke Mortality A Statement From the American Heart Association/American Stroke Association
Daniel T. Lackland,Edward J. Roccella,Anne Deutsch,Myriam Fornage,Mary G. George,George Howard,Brett M. Kissela,Steven J. Kittner,Judith H. Lichtman,Lynda D. Lisabeth,Lee H. Schwamm,Eric E. Smith,Amytis Towfighi +12 more
TL;DR: There is strong evidence that the decline in stroke mortality can be attributed to a combination of interventions and programs based on scientific findings and implemented with the purpose of reducing stroke risks, the most likely being improved control of hypertension.
Journal ArticleDOI
Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension
Empar Lurbe,Renata Cifkova,J. Kennedy Cruickshank,M J Dillon,Isabel Ferreira,Cecilia Invitti,Tatiana Kuznetsova,Stéphane Laurent,Giuseppe Mancia,Francisco J. Morales-Olivas,Wolfgang Rascher,Josep Redon,Franz Schaefer,Tomáš Seeman,George S. Stergiou,Elke Wühl,Alberto Zanchetti +16 more
TL;DR: These guidelines represent a consensus among specialists involved in the detection and control of high blood pressure in children and adolescents and represent best clinical wisdom upon which physicians, nurses and families should base their decisions.
Journal ArticleDOI
Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.
Paolo Verdecchia,Jan A. Staessen,Jan A. Staessen,Fabio Angeli,Giovanni de Simone,Augusto Achilli,Antonello Ganau,Gian Francesco Mureddu,Sergio Pede,Aldo P. Maggioni,Donata Lucci,Gianpaolo Reboldi +11 more
TL;DR: The findings lend support to a lower blood pressure goal than is recommended at present in non-diabetic patients with hypertension.
References
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Journal ArticleDOI
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
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TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
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Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.
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Journal ArticleDOI
Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
TL;DR: Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or heart failure.
Journal Article
Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
M R Stearne,S L Palmer,M S Hammersley,S L Franklin,R S Spivey,Jonathan C. Levy,C R Tidy,N J Bell,J Steemson,B A Barrow,R Coster,K Waring,J Nolan,E Truscott,N Walravens,L Cook,H Lampard,C Merle,P Parker,J McVittie,I Draisey,L E Murchison,A H E Brunt,M J Williams,D W Pearson,X M P Petrie,M E J Lean,D Walmsley,M J Lyall,E Christie,J Church,E Thomson,A Farrow,J M Stowers,M Stowers,K McHardy,N Patterson,Alex D. Wright,N A Levi,A C I Shearer,R J W Thompson,G Taylor,S Rayton,M Bradbury,A Glover,A Smyth-Osbourne,C Parkes,J Graham,P England,S Gyde,C Eagle,B Chakrabarti,Josh Smith,J Sherwell,E M Kohner,A Dornhurst,M C Doddridge,M Dumskyj,S Walji,P Sharp,M Sleightholm,G Vanterpool,C Rose,G Frost,M Roseblade,S Elliott,S Forrester,Meredith C. Foster,K Myers,R Chapman,J R Hayes,R W Henry,M S Featherston,G P R Archbold,M Copeland,R Harper,I Richardson,S Martin,H A Davison,D R Hadden,L Kennedy,A B Atkinson,A M Culbert,C Hegan,H Tennet,N Webb,I Robinson,J Holmes,P M Bell,D R McCance,J Rutherford,S Nesbitt,A S Spathis,S Hyer,M E Nanson,L M James,J M Tyrell,C Davis,P Strugnell,M Booth,H Petrie,D Clark,B Rice,S Hulland,J L Barron,J S Yudkin,B J Gould,J Singer,A Badenock,M Eckert,K Alibhai,E Marriot,Christopher E. Cox,R Price,M Fernandez,A Ryle,S Clarke,G Wallace,E Mehmed,S MacFarlane,R H Greenwood,J Wilson,M J Denholm,R C Temple,K Whitfield,F Johnson,C Munroe,S Gorick,E Duckworth,M Flatman,S Rainbow,L J Borthwick,D J Wheatcroft,R J Seaman,R A Christie,W Wheatcroft,P Musk,Jennifer White,S McDougal,M Bond,P Raniga,R W Newton,R T Jung,C Roxburgh,B Kilgallon,L Dick,N Waugh,S Kilby,A Ellingford,J Burns,C Fox,M C Holloway,H M Coghill,N Hein,A J Fox,W Cowan,M Richard,K Quested,S J Evans,Richard B Paisey,N P R Brown,A J Tucker,R Paisey,F Garrett,J Hogg,P Park,K Williams,P Harvey,R Wilcocks,S Mason,J. C. Frost,C Warren,P Rocket,L Bower,J M Roland,D J Brown,J Youens,K Stanton-King,H Mungall,W Maddison,D Donnelly,S King,P Griffin,Sidney C. Smith,S Church,Graham Dunn,Andrew D. Wilson,K Palmer,P M Brown,D Humphriss,A J M Davidson,Richard Rose,L Armistead,S Townsend,P Poon,I D A Peacock,N J C Culverwell,M H Charlton,B P S Connolly,J Peacock,J Barrett,J Wain,W Beeston,George L. King,P G Hill,Andrew J.M. Boulton,A M Robertson,Katoulis,A Olukoga,H McDonald,S Kumar,F Abouaesha,B Abuaisha,E A Knowles,S Higgins,J Booker,J Sunter,K Breislin,R Parker,P Raval,J Curwell,H Davenport,G Shawcross,A Prest,J Grey,H Cole,C Sereviratne,R J Young,Tim Dornan,J R Clyne,M Gibson,I O'Connell,L M Wong,S J Wilson,K L Wright,Chris Wallace,D McDowell,A C Burden,E M Sellen,R Gregory,M Roshan,N Vaghela,M Burden,C Sherriff,J Clarke,J Grenfell,Je Tooke,K. M. MacLeod,C Searnark,M Rammell,C Pym,J Stockman,C Yeo,J Piper,L Leighton,Ellen Green,M Hoyle,K Jones,A Hudson,A J James,Angela C. Shore,A Higham,B Martin +262 more
TL;DR: Tight blood pressure control in patients with hypertension and type 2 diabetes achieves a clinically important reduction in the risk of deaths related to diabetes, complications related to Diabetes, progression of diabetic retinopathy, and deterioration in visual acuity.