Journal ArticleDOI
Fast and robust online adaptive planning in stereotactic MR-guided adaptive radiation therapy (SMART) for pancreatic cancer.
Omar Bohoudi,Anna M.E. Bruynzeel,Suresh Senan,Johan P. Cuijpers,Berend J. Slotman,Frank J. Lagerwaard,Miguel A. Palacios +6 more
TLDR
SMART3CM approach for LAPC allows good OAR sparing and adequate target coverage while requiring only limited online (re-)contouring from clinicians.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-12-01. It has received 234 citations till now.read more
Citations
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MR-guidance in clinical reality: Current treatment challenges and future perspectives
Stefanie Corradini,Filippo Alongi,Nicolaus Andratschke,Claus Belka,Luca Boldrini,Francesco Cellini,Jürgen Debus,Jürgen Debus,Matthias Guckenberger,J. Hörner-Rieber,J. Hörner-Rieber,Frank J. Lagerwaard,Rosario Mazzola,Miguel A. Palacios,Marielle E.P. Philippens,Cornelis P.J. Raaijmakers,C.H.J. Terhaard,Vincenzo Valentini,Maximilian Niyazi +18 more
TL;DR: The focus of the present preview was on the initial applicability in current clinical practice and on future perspectives of this new technology for different treatment sites, considered a groundbreaking new technology that is capable of creating new perspectives towards an individualized, patient-oriented planning and treatment approach.
Journal ArticleDOI
Using adaptive magnetic resonance image-guided radiation therapy for treatment of inoperable pancreatic cancer.
Soumon Rudra,Naomi Jiang,Stephen A. Rosenberg,Jeffrey R. Olsen,Michael C. Roach,Leping Wan,Lorraine Portelance,Eric A. Mellon,Anna M.E. Bruynzeel,Frank J. Lagerwaard,Michael F. Bassetti,Parag J. Parikh,Percy Lee +12 more
TL;DR: Outcomes of inoperable pancreatic cancer patients treated using MRgRT with and without dose escalation are evaluated.
Journal ArticleDOI
Technical design and concept of a 0.35 T MR-Linac
TL;DR: The 0.35 T MR-Linac combines a 6MV linac with onboard MR imaging that provides superior soft-tissue contrast compared to X-ray IGRT and allows a fully integrated on-table adaptive workflow.
Journal ArticleDOI
Adaptive radiotherapy for anatomical changes
TL;DR: An overview of anatomical changes occurring over the course of therapy and various adaptive strategies developed to account for those is provided as well as required tools, potential pitfalls and remaining challenges.
Journal ArticleDOI
Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy: A "Game Changer" for Prostate Treatment?
A. Pathmanathan,Nicholas van As,Linda G W Kerkmeijer,John Christodouleas,Colleen A. Lawton,Danny Vesprini,Uulke A. van der Heide,Steven J. Frank,Simeon Nill,Uwe Oelfke,Marcel van Herk,X. Allen Li,K Mittauer,Mark A. Ritter,Ananya Choudhury,Alison Tree +15 more
TL;DR: The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.
References
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Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05.
Edward G. Shaw,Charles Scott,Luis Souhami,Robert P. Dinapoli,Robert W. Kline,Jay S. Loeffler,Nancy C. Farnan +6 more
TL;DR: The maximum tolerated doses of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases were defined for this population of patients as 24 Gy, 18 Gy, and 15 Gy for tumors, whereas investigators' reluctance to escalate to 27 Gy, rather than excessive toxicity, determined the maximum tolerated dose.
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The ViewRay System: Magnetic Resonance–Guided and Controlled Radiotherapy
Sasa Mutic,James F. Dempsey +1 more
TL;DR: The on-couch adaptive RT treatment-planning system and integrated MRI-guided RT control system allow for rapid adaptive planning and beam delivery control based on the visualization of soft tissues.
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Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer.
Albert C. Koong,Q.T. Le,Anthony Ho,Bryan Fong,George A. Fisher,Cheryl D. Cho,James M. Ford,Joseph C. Poen,Iris C. Gibbs,Vivek K. Mehta,Stephen T. Kee,Ward Trueblood,George P. Yang,J. Augusto Bastidas +13 more
TL;DR: It is feasible to deliver stereotactic radiosurgery to patients with locally advanced pancreatic cancer and the recommended dose to achieve local control without significant acute gastrointestinal toxicity is 25 Gy.
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Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas.
Daniel T. Chang,Devin Schellenberg,John Shen,Jeff Kim,Karyn A. Goodman,George A. Fisher,James M. Ford,Terry S. Desser,Andrew Quon,Albert C. Koong +9 more
TL;DR: The authors report on the local control and toxicity of stereotactic body radiotherapy (SBRT) for patients with unresectable pancreatic adenocarcinoma.
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Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer
Devin Schellenberg,Karyn A. Goodman,Florence Lee,Stephanie T. Chang,Timothy Kuo,James M. Ford,George A. Fisher,Andrew Quon,Terry S. Desser,Jeffrey A. Norton,Ralph S. Greco,George P. Yang,Albert C. Koong +12 more
TL;DR: SBRT with gemcitabine resulted in comparable survival to conventional chemoradiotherapy and good local control, however, the rate of duodenal ulcer development was significant.
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Bas W. Raaymakers,I.M. Jürgenliemk-Schulz,Gijsbert H. Bol,M Glitzner,Alexis N.T.J. Kotte,B. Van Asselen,J. de Boer,J.J. Bluemink,S.L. Hackett,Marinus A. Moerland,S J Woodings,J.W.H. Wolthaus,H M van Zijp,M.E.P. Philippens,Rob H N Tijssen,J G M Kok,E.N. De Groot-van Breugel,I.H. Kiekebosch,L.T.C. Meijers,C.N. Nomden,G.G. Sikkes,Patricia Doornaert,Wietse S.C. Eppinga,Nicolien Kasperts,Linda G W Kerkmeijer,J.H.A. Tersteeg,Kristy J. Brown,B. R. Pais,P. Woodhead,Jan J W Lagendijk +29 more