Journal ArticleDOI
Fatty Acid-Binding Proteins and Their Physiological Significance
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Fatty acid-binding proteins are found in extraordinary abundance in cells of mammalian tissues that are actively involved in the uptake or utilization of fatty acids, such as intestine, liver, and heart.Abstract:
Fatty acid-binding proteins are found in extraordinary abundance in cells of mammalian tissues that are actively involved in the uptake or utilization of fatty acids, such as intestine, liver, and heart. They are small proteins, and different tissues contain distinct types. They are typically considered to be the intracellular counterpart of serum albumin and are thought to play an extensive role in cellular lipid homeostasis.read more
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Journal ArticleDOI
Liver fatty acid-binding protein and obesity
Barbara P. Atshaves,Gregory G. Martin,Heather A. Hostetler,Avery L. McIntosh,Ann B. Kier,Friedhelm Schroeder +5 more
TL;DR: Data suggest that L-FABP could have an important role in preventing age- or diet-induced obesity and in reducing hepatic LCFA uptake/oxidation and increasing LCFAs available for oxidation in muscle and/or storage in adipose.
Journal ArticleDOI
Role of Acyl-CoA Binding Protein in Acyl-CoA Metabolism and Acyl-CoA–Mediated Cell Signaling
TL;DR: Preliminary evidence indicates that the regulatory effect of LCA might be mediated by the LCA/ACBP complex and two to four orders of magnitude lower than the concentrations reported to be necessary to regulate most LCA-affected cellular functions.
Journal ArticleDOI
Fatty acid-binding protein and its relation to fatty acid oxidation
TL;DR: A relation between fatty acid oxidation capacity and cytosolic FABP content was found in heart and various muscles of the rat and only it increased in fast-twitch muscles upon chronic electrostimulation and endurance training.
Journal ArticleDOI
Cellular fatty acid-binding proteins: current concepts and future directions
TL;DR: Current knowledge suggests that the function of this set of proteins reaches beyond simply aiding cytoplasmic solubilization of hydrophobic ligands, but that they can be assigned several regulatory roles in cellular lipid homeostasis.
Book ChapterDOI
Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling
Jens Knudsen,Mette Valentin Jensen,Jan Krogh Hansen,Nils J. Færgeman,Thomas B. F. Neergaard,Barbara Gaigg +5 more
TL;DR: AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions.