Journal ArticleDOI
Fetal survival after prednisone suppression of maternal lupus-anticoagulant
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TLDR
The presence of the lupus anticoagulant was diagnosed in six pregnant women because they had prolonged activated partial thromboplastin and kaolin clotting times which could not be corrected by dilution of test samples with normal plasma.About:
This article is published in The Lancet.The article was published on 1983-06-18. It has received 406 citations till now. The article focuses on the topics: Lupus anticoagulant & Partial thromboplastin time.read more
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Antiphospholipid Antibodies: Anticardiolipin and the Lupus Anticoagulant in Systemic Lupus Erythematosus (SLE) and in Non-SLE Disorders
Paul E. Love,Samuel A. Santoro +1 more
TL;DR: In this article, the prevalence of lupus anticoagulant and anticardiolipin in systemic Lupus erythematosus (SLE) and in non-SLE disorders was determined.
Journal ArticleDOI
Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)
TL;DR: The prognosis for pregnancies in women with recurrent miscarriage associated with phospholipid antibodies is poor but this randomised controlled trial found that the prognosis improved with low dose aspirin and was further improved with the addition of low dose heparin to the aspirin.
Journal ArticleDOI
Antiphospholipid Antibodies: Anticardiolipin and the Lupus Anticoagulant in Systemic Lupus Erythematosus (SLE) and in Non-SLE Disorders: Prevalence and Clinical Significance
Paul E. Love,Samuel A. Santoro +1 more
TL;DR: The results of predominantly retrospective series suggest that for certain persons (patients with SLE or closely related disorders) antiphospholipid antibodies may be important risk factors for thrombosis, neurologic disease,Thrombocytopenia, and fetal loss.
Journal ArticleDOI
Thrombosis, abortion, cerebral disease, and the lupus anticoagulant.
TL;DR: Few diabetics register on the Disabled Persons Register, but those with disabling complications may find it advantageous to do so and to seek the advice of their local disablement resettlement officer.
Journal ArticleDOI
Use of Antithrombotic Agents During Pregnancy
Jeffrey S. Ginsberg,Jack Hirsh +1 more
TL;DR: Oral anticoagulant therapy should be avoided in the weeks before delivery because of the risk of serious perinatal bleeding caused by the trauma of delivery to the antICOagulated fetus, and the safety of aspirin during the first trimester of pregnancy is still a subject of debate.
References
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Journal ArticleDOI
Arterial thrombosis, intrauterine death and "lupus" anticoagulant: detection of immunoglobulin interfering with prostacyclin formation
L O Carreras,S. J. Machin,Rene Deman,Ghislain Defreyn,Jos Vermylen,Bernard Spitz,André Van Assche +6 more
TL;DR: In a 31-year-old woman with a history of recurrent arterial thrombosis, a "lupus" anticoagulant was identified and an antibody in this patient may interfere with the production or release of PGI2 by the vessel wall, possibly by interfering with the availability of arachidonic acid.
Journal ArticleDOI
Thrombosis in Patients with the Lupus Anticoagulant
TL;DR: It is suggested that patients with the lupus anticoagulant may be at increased risk of thrombosis.
Journal Article
A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus
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A clinical study of the lupus anticoagulant
TL;DR: The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients and was augmented in 67% of these patients by a cofactor present in normal plasma.