Journal ArticleDOI
Flavonoids and Dementia: An Update
Ilkay Erdogan Orhan,Maria Daglia,Seyed Fazel Nabavi,Monica Rosa Loizzo,Eduardo Sobarzo-Sánchez,S M Nabavi +5 more
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TLDR
The present article is aimed at reviewing scientific studies that show the protective effects of flavonoid intake against mild cognitive impairment and dementia.Abstract:
Dementia is a strongly age-related syndrome due to cognitive decline that can be considered a typical example of the combination of physiological and pathological aging-associated changes occurring in old people; it ranges from intact cognition to mild cognitive impairment, which is an intermediate stage of cognitive deterioration, and dementia. The spread of this syndrome has induced to study and try to reduce dementia modifiable risk factors. They include insulin resistance and hyperinsulinaemia, high blood pressure, obesity, smoking, depression, cognitive inactivity or low educational attainment as well as physical inactivity and incorrect diet, which can be considered one of the most important factors. One emerging strategy to decrease the prevalence of mild cognitive impairment and dementia may be the use of nutritional interventions. In the last decade, prospective data have suggested that high fruit and vegetable intakes are related to improved cognitive functions and reduced risks of developing a neurodegenerative process. The protective effects against neurodegeneration could be in part due to the intake of flavonoids that have been associated with several health benefits such as antioxidant and anti-inflammatory activities, increased neuronal signaling, and improved metabolic functions. The present article is aimed at reviewing scientific studies that show the protective effects of flavonoid intake against mild cognitive impairment and dementia.read more
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Journal ArticleDOI
Important Flavonoids and Their Role as a Therapeutic Agent.
Asad Ullah,S M Munir,Syed Lal Badshah,Noreen Khan,Lubna Ghani,Benjamin Gabriel Poulson,Abdul-Hamid M. Emwas,Mariusz Jaremko +7 more
TL;DR: This work has made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.
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Luteolin as an anti-inflammatory and neuroprotective agent: A brief review
Seyed Fazel Nabavi,Nady Braidy,Olga Gortzi,Eduardo Sobarzo-Sánchez,Maria Daglia,Krystyna Skalicka-Woźniak,Seyed Mohammad Nabavi +6 more
TL;DR: The available literature regarding the neuroprotective effects of luteolin, its herbal sources, and bioavailability as a pharmacological agent for the treatment and management of age-related neurodegenerative disorders are reviewed.
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Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds.
Ammad Ahmad Farooqi,Nishil N. Desai,Muhammad Zahid Qureshi,Daniele Rubert Nogueira Librelotto,Maria Luisa Gasparri,Maria Luisa Gasparri,Anupam Bishayee,Seyed Mohammad Nabavi,Valeria Curti,Maria Daglia +9 more
TL;DR: This review summarizes the most recent developments in exosome bioactivities and discusses the biochemical nature of exosomes and their biogenesis, and summarizes the use ofExosomes as delivery vehicles for drugs and natural compounds to the targeted site.
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The effects of baicalein and baicalin on mitochondrial function and dynamics: A review.
Marcos Roberto de Oliveira,Seyed Fazel Nabavi,Solomon Habtemariam,Ilkay Erdogan Orhan,Maria Daglia,Seyed Mohammad Nabavi +5 more
TL;DR: The promising role of baicalin and its aglycone form, baicalein, on mitochondrial function and structure with a focus on its therapeutic effects is highlighted and their chemistry, sources and bioavailability are discussed.
Journal ArticleDOI
Hepatoprotective effect of quercetin: From chemistry to medicine.
Davide Barreca,Ersilia Bellocco,Grazia D'Onofrio,Seyed Fazel Nabavi,Maria Daglia,Luca Rastrelli,Seyed Mohammad Nabavi +6 more
TL;DR: Overall, data in literature shows that QE appears to be a promising hepatoprotective compound, including anti-oxidative, anti-inflammatory,Anti-apoptotic and hepatoprotsective activities against various hepatic ailments.