Journal ArticleDOI
Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities
Anish Kundu,Adinpunya Mitra +1 more
TLDR
Fragrant plant extracts traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, are explored as possible sources for AChEI, and plant-based food flavoring agents showed capacity in curing Alzheimer’s disease and other neurological dysfunctions.Abstract:
Acetylcholinesterase inhibitors (AChEIs) are important for treatment of Alzheimer's disease and other neurological disorders. Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, as possible sources for AChEI. Root and pod extracts of H. indicus and V. planifolia, respectively, produce fragrant phenolic compounds, 2-hydroxy-4-methoxybenzaldehyde (MBALD) and 4-hydroxy-3-methoxybenzaldehyde (vanillin). These methoxybenzaldehydes were shown to have inhibitory potential against acetylcholinesterase (AChE). Vanillin (IC50 = 0.037 mM) was detected as more efficient inhibitor than MBALD (IC50 = 0.047 mM). This finding was supported by kinetic analysis. Thus, plant-based food flavoring agents showed capacity in curing Alzheimer's disease and other neurological dysfunctions.read more
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Journal ArticleDOI
The Role of Food Antioxidants, Benefits of Functional Foods, and Influence of Feeding Habits on the Health of the Older Person: An Overview
Douglas W. Wilson,Douglas W. Wilson,Paul Nash,Harpal S. Buttar,Keith Griffiths,Ram B. Singh,Fabien De Meester,Rie Horiuchi,Toru Takahashi +8 more
TL;DR: This overview was directed towards understanding the relationship of brain functions with dietary choices mainly by older humans, as they relate to dietary sufficiency or the association of antioxidants with neurodegenerative diseases such as dementia and Alzheimer’s disease.
Journal ArticleDOI
Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health – a comprehensive review
Mahmoud Alagawany,Shaaban S Elnesr,Mayada R. Farag,Ruchi Tiwari,Mohd Iqbal Yatoo,Kumaragurubaran Karthik,Izabela Michalak,Kuldeep Dhama +7 more
TL;DR: In this review, the uses of amino acids, vitamins and minerals as well as their mode of action in growth promotion and elevation of immune system are discussed.
Book ChapterDOI
Pharmacogenomics of Alzheimer's disease: novel therapeutic strategies for drug development.
TL;DR: Future perspectives for the global management of AD predict that genomics and proteomics may help in the search for reliable biomarkers, and the implementation of pharmacogenomic strategies will contribute to optimize drug development and therapeutics in AD and related disorders.
Journal ArticleDOI
Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington's disease.
Surbhi Gupta,Bhupesh Sharma +1 more
TL;DR: It is concluded that agomelatine and vanillin may provide benefits in HD because they exhibit protective effects against 3-NPA induced HD.
Journal ArticleDOI
Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase
Sagheer Ahmed,Sidrah Tariq Khan,Muhammad Kazim Zargaham,Arif Ullah Khan,Saeed Khan,Abrar Hussain,Jalal Uddin,Ajmal Khan,Ahmed Al-Harrasi +8 more
TL;DR: In this article, the authors summarize the studies reporting phytocompounds and extracts from medicinal plants that show AChE inhibitory activities and could be of potential benefit in Alzheimer's disease.
References
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Journal ArticleDOI
Acetylcholinesterase inhibitors from plants
TL;DR: This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity and reports numerous phytoconstituents and promising plant species as A ChE inhibitors.
Journal ArticleDOI
Primary mutagenicity screening of food additives currently used in Japan
TL;DR: Salmonella/microsome tests (Ames tests) and chromosomal aberration tests in vitro using a Chinese hamster fibroblast cell line were carried out on 190 synthetic food additives and 52 food additives derived from natural sources, all of which are currently used in Japan.
Journal ArticleDOI
Bioactive compounds and health-promoting properties of berry fruits: a review.
A. Szajdek,E. J. Borowska +1 more
TL;DR: This study characterizes biologically active compounds of berry fruits, including non-nutritive compounds such as phenolic compounds, including anthocyanins, phenolic acids, stilbens and tannins, as well as nutritive compoundssuch as carotenoids and vitamin C.
Journal ArticleDOI
Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study.
David Bachman,Philip A. Wolf,Richard T. Linn,Janice E. Knoefel,Janet L. Cobb,Albert M. Belanger,Ralph B. D'Agostino,Lon R. White +7 more
TL;DR: Prevalence of dementia and orobable SDAT were greater for women than men and increased with advancing age, and the fema1e:male ratio of prevalence for cohort members 75 years of age and older was 1.8 for all cases of Alzheimer type dementia and 2.7 for cases of probable SDAT.