Journal ArticleDOI
Fluorinated Sterols Part II: 26,27-polyfluorinated desmosterols
TLDR
In this article, the synthesis of polyfluorinated desmosterols by a Wittig condensation between a steroidal triphenylphosphonium ylid and polyfluoroacetone was described.About:
This article is published in Journal of Fluorine Chemistry.The article was published on 1976-09-01. It has received 7 citations till now. The article focuses on the topics: Wittig reaction.read more
Citations
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Journal ArticleDOI
The chemistry of propargylic and allylic fluorides.
Journal ArticleDOI
Fluorierungsmethoden in der Organischen Chemie
TL;DR: In this paper, a vorliegende Ubersicht is given, der Versuch einer Dokumentation und Klassifizierung der methoden sowie eine kritische Wurdigung, nicht zulether unter dem Aspekt von Effizienz und Wirtschaftlichkeit.
Patent
Liver x receptor agonists
TL;DR: A compound of formula (I) is defined as a compound in which a C=C bond is formed between the carbons to which they are attached as discussed by the authors, and each of R1, R2, R3, R4, R5, R6, R7, R11, R12, R15, R16, and R17, independently, is hydrogen, halo, alkyl, hydroxyalkyl, alkoxy, or amino; n is 0, 1, or 2.
Patent
Method Of Treating Disorder Related To High Cholesterol Concentration
TL;DR: In this article, a method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I), was described, where an activator of liver X alpha is indicated, such as in, for example, treating high cholesterol disease.
Journal ArticleDOI
Synthesis of cholesterol and its analogs with fluorinated side-chains
TL;DR: Dithionite initiated addition of perfluoroalkyl iodide to an olefinic double bond proved to be an efficient method for the introduction of a perfluoralkyl group to a steroid side chain this paper.
References
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Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney.
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Mass spectrometry in structural and stereochemical problems. CXLVI. Mass spectrometric fragmentations typical of sterols wit unsaturated side chains
S. G. Wyllie,Carl Djerassi +1 more
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Characterization of sterols by gas chromatography-mass spectrometry of the trimethylsilyl ethers.
TL;DR: The utility of combined gas chromatography-mass spectrometry in the analysis and characterization of sterols has been explored and positive identification of any of the sterols examined is allowed, whereas application of either technique alone may give inconclusive results.
Journal ArticleDOI
Metabolism of cholesterol in the chick embryo. II. Isolation and chemical nature of two companion sterols.
Journal ArticleDOI
Einfluss funktioneller Gruppen auf die Massenspektren von 17β-Hydroxysteroiden
TL;DR: In this article, the authors studied the effect of functional groups on fragmentation reactions in 17β-hydroxy-5α-androstanes and found that the hydroxyl group only predominates as long as substituents are absent which need less energy for ionization than is necessary.