Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation.
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TLDR
O-Tyr and DT should be useful chemical markers of cumulative exposure of proteins to MCO in vitro and in vivo, according to their usefulness as chemical indicators of cumulative oxidative damage to proteins.About:
This article is published in Journal of Biological Chemistry.The article was published on 1993-06-15 and is currently open access. It has received 227 citations till now. The article focuses on the topics: Fluorescence spectrometry.read more
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Free radical-mediated oxidation of free amino acids and amino acid residues in proteins.
TL;DR: It is evident that the cyclic oxidation and reduction of the sulfur-containing amino acids may serve as an important antioxidant mechanism, and also that these reversible oxidations may provide an important mechanism for the regulation of some enzyme functions.
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Biochemistry and pathology of radical-mediated protein oxidation
TL;DR: Proteins are also key targets in defensive cytolysis and in inflammatory self-damage, and the possibility of selective protection against protein oxidation (antioxidation) is raised.
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Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants.
TL;DR: Current knowledge and advances in the understanding of oxidative processes in biological systems are summarized and this knowledge is extended to specific applications in aquatic organisms because of their sensitivity to oxidative pollutants, their filtration capacity, and their potential for environmental toxicology studies.
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Protein oxidation and aging
TL;DR: The importance of protein oxidation in aging is supported by the observation that levels of oxidized proteins increase with animal age and may reflect age-related increases in rates of ROS generation, decreases in antioxidant activities, or losses in the capacity to degrade oxidized protein.
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Biomarkers of free radical damage: Applications in experimental animals and in humans
TL;DR: This review gives an overview of the applications in experimental and human situations of four main groups of products resulting from free radical damage, these include: lipid peroxidation products, isoprostanes, DNA-hydroxylation products and protein hydroxylated products.
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Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'