Fourth European Conference on Infections in Leukaemia (ECIL-4): Guidelines for Diagnosis and Treatment of Human Respiratory Syncytial Virus, Parainfluenza Virus, Metapneumovirus, Rhinovirus, and Coronavirus
Hans H. Hirsch,Rodrigo Martino,Katherine N. Ward,Michael Boeckh,Hermann Einsele,Per Ljungman +5 more
TLDR
The risk for lower respiratory tract infections and a fatal outcome appears to depend on the intrinsic virulence of the specific community-acquired respiratory virus as well as factors specific to the patient, the underlying disease, and its treatment.Abstract:
Community-acquired respiratory virus (CARV) infections have been recognized as a significant cause of morbidity and mortality in patients with leukemia and those undergoing hematopoietic stem cell transplantation (HSCT). Progression to lower respiratory tract infection with clinical and radiological signs of pneumonia and respiratory failure appears to depend on the intrinsic virulence of the specific CARV as well as factors specific to the patient, the underlying disease, and its treatment. To better define the current state of knowledge of CARVs in leukemia and HSCT patients, and to improve CARV diagnosis and management, a working group of the Fourth European Conference on Infections in Leukaemia (ECIL-4) 2011 reviewed the literature on CARVs, graded the available quality of evidence, and made recommendations according to the Infectious Diseases Society of America grading system. Owing to differences in screening, clinical presentation, and therapy for influenza and adenovirus, ECIL-4 recommendations are summarized for CARVs other than influenza and adenovirus.read more
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Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection
Michael T. Brady,Carrie L. Byington,H. Dele Davies,Kathryn M. Edwards,Mary Anne Jackson,Yvonne Maldonado,Dennis L. Murray,Walter A. Orenstein,Mobeen H. Rathore,Mark H. Sawyer,Gordon E. Schutze,Rodney E. Willoughby,Theoklis E. Zaoutis,Henry H. Bernstein,David W. Kimberlin,Sarah S. Long,H. Cody Meissner,Marc A. Fischer,Bruce G. Gellin,Richard L. Gorman,Lucia H. Lee,R. Douglas Pratt,Jennifer S. Read,Joan L. Robinson,Marco Aurélio Palazzi Sáfadi,Jane F. Seward,Jeffrey R. Starke,Geoffrey R. Simon,Tina Q. Tan,Joseph A. Bocchini,W. Robert Morrow,Larry K. Pickering,Geoffrey L. Rosenthal,Dan L. Stewart,Jennifer Frantz,Shawn L. Ralston,Allan S. Lieberthal,Brian Alverson,Jill E. Baley,Anne Gadomski,David W. Johnson,Michael J. Light,Nizar Maraqa,Eneida A. Mendonça,Kieran J. Phelan,Joseph J. Zorc,Danette Stanko-Lopp,Sinsi Hernandez-Cancio,Mark A. Brown,Ian Nathanson,Elizabeth Rosenblum,Stephen Sayles,Caryn Davidson +52 more
TL;DR: The updated recommendations in this policy statement reflect new information regarding the seasonality of RSV circulation, palivizumab pharmacokinetics, the changing incidence of bronchiolitis hospitalizations, the effect of gestational age and other risk factors on RSV hospitalization rates, the mortality of children hospitalized with RSV infection, the effects of prophylaxis on wheezing, and palivZumab-resistant RSV isolates.
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COVID-19: what has been learned and to be learned about the novel coronavirus disease.
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A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group.
Humaid O. Al-Shamsi,Waleed Alhazzani,Ahmad Alhuraiji,Eric A. Coomes,Roy F. Chemaly,Meshari Almuhanna,Robert A. Wolff,Nuhad K. Ibrahim,Melvin L.K. Chua,Sebastien J. Hotte,Brandon M. Meyers,Tarek Elfiki,Giuseppe Curigliano,Cathy Eng,Axel Grothey,Conghua Xie +15 more
TL;DR: The potential challenges associated with managing cancer patients during the COVID‐19 infection pandemic will be addressed, with suggestions of some practical approaches.
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