Journal ArticleDOI
Frequency of Major Complications of Aspirin, Warfarin, and Intravenous Heparin for Secondary Stroke Prevention: A Population-Based Study
George W. Petty,Robert D. Brown,Jack P. Whisnant,Jo Rean D. Sicks,W. Michael O'Fallon,David O. Wiebers +5 more
TLDR
The rates of complications associated with medical therapy for secondary stroke prevention for all patients with first episodes of cerebral ischemia or amaurosis fugax in a defined community are determined to assess the generalizability of complication rates derived from clinical trials for these therapies.Abstract:
In this study, complication rates for warfarin and intravenous heparin given for secondary stroke prevention were lower than rates reported from earlier trials and observational studies. For warfar...read more
Citations
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Journal ArticleDOI
CYP4F2 genetic variant alters required warfarin dose.
Michael D. Caldwell,Tarif Awad,Julie A. Johnson,Brian F. Gage,Mat Falkowski,Paul Gardina,Jason Hubbard,Yaron Turpaz,Taimour Y. Langaee,Charles S. Eby,Cristi R. King,Amy Brower,John R. Schmelzer,Ingrid Glurich,Humberto Vidaillet,Steven H. Yale,Kai Qi Zhang,Richard L. Berg,James K. Burmester +18 more
TL;DR: A novel variant in cytochrome P450 4F2 (CYP4F2) was associated with warfarin dose in 3 independent white cohorts of patients stabilized on war Farfarin representing diverse geographic regions in the United States and accounted for a difference in warFarin dose of approximately 1 mg/day between CC and TT subjects.
Journal ArticleDOI
Genetic susceptibility to adverse drug reactions.
Munir Pirmohamed,B. Kevin Park +1 more
TL;DR: In the future, whole genome single nucleotide polymorphism (SNP) profiling might allow an unbiased method of determining genetic predisposing factors for ADRs, but might be limited by the lack of adequate numbers of patient samples.
Journal ArticleDOI
Adverse Outcomes and Predictors of Underuse of Antithrombotic Therapy in Medicare Beneficiaries With Chronic Atrial Fibrillation
Brian F. Gage,Michael Boechler,Amy L. Doggette,Gary Fortune,Greg C. Flaker,Michael W. Rich,Martha J. Radford +6 more
TL;DR: The underuse of antithrombotic therapy in Medicare beneficiaries who have NVAF is associated with measurable adverse outcomes, and the benefit of warfarin therapy may extend to frail, elderly patients, a group that was excluded from randomized controlled trials.
Journal ArticleDOI
A clinical prediction rule to identify patients with atrial fibrillation and a low risk for stroke while taking aspirin.
Carl van Walraven,Robert G. Hart,George A. Wells,Palle Petersen,Peter J. Koudstaal,Annette Lemche Gulløv,Beppie S. P. Hellemons,Birgitte G. Koefed,Andreas Laupacis +8 more
TL;DR: Irrespective of age, patients with AF and none of these 4 clinical features and who take aspirin have stroke rates comparable to those of age-matched community cohorts and would not benefit substantially from anticoagulation.
References
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Cerebral vascular accidents in patients over the age of 60. II. Prognosis.
TL;DR: A survey was carried out on a number of 'untreated' cases seen shortly after the onset of a cerebral vascular accident, with particular reference to the presence of signs which had prognostic value, to enable the investigator to assess the results of specific forms of treatment.
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History of the Rochester Epidemiology Project
TL;DR: The Rochester Epidemiology Project is a unique medical records-linkage system that encompasses the care delivered to residents of Rochester and Olmsted County, Minnesota and is able to provide accurate incidence data for almost any serious condition and to support population-based analytic studies of disease causes and outcomes.
Journal ArticleDOI
Hemorrhagic Complications of Anticoagulant Treatment
TL;DR: There is good evidence that low-intensity oral anticoagulant therapy (targeted INR of 2.5; range, 2.0 to 3.0) is associated with a lower risk of bleeding than therapy targeted at a higher intensity, and Lower-intensity regimens (INR 70 years).
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Risk Factors for Intracranial Hemorrhage in Outpatients Taking Warfarin
Elaine M. Hylek,Daniel E. Singer +1 more
TL;DR: A casecontrol study focused exclusively on intracranial hemorrhage occurring among outpatients taking warfarin, drawing on an 11-year experience of one general hospital to provide case-patients and using the same hospital's large anticoagulant therapy unit to provide contemporaneous controls who were also takingwarfarin.
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Anticoagulant-related bleeding: Clinical epidemiology, prediction, and prevention
TL;DR: The risk for bleeding can be estimated in an individual patient, giving the primary physician a quantitative basis for weighing the risks and benefits of therapy and for optimizing patient management.