Frontal function and executive processing in older adults: process and region specific age-related longitudinal functional changes.
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TLDR
Examination of individual differences through cross-sectional associations at baseline evaluation and longitudinal changes in regional cerebral blood flow in relation to different executive abilities in cognitively normal older adults suggests process- and region-specific, rather than uniform, age-related changes in frontal brain-behavior associations, and suggests that longitudinally high-levels of frontal engagement reflect declining rather than stable cognition.About:
This article is published in NeuroImage.The article was published on 2013-04-01 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Aging brain & Longitudinal study.read more
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Reduced functional segregation between the default mode network and the executive control network in healthy older adults: A longitudinal study.
TL;DR: This work found progressive loss of functional specialization with ageing, evidenced by a decline in intra-network FC within the executive control (ECN) and default mode networks (DMN) among healthy older adults.
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Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity.
TL;DR: It is demonstrated that HT can prevent the appearance of reduced prefrontal cortex activity, a neurophysiological measure observed both in healthy aging and early dementia.
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Connectome-based models predict attentional control in aging adults.
TL;DR: The results support the saCPM's ability to capture attention‐related patterns reflected in each individual's functional connectivity signature across both task context and age, and it is these connections that better account for age‐related deficits in attentional control.
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Mindfulness Training for Healthy Aging: Impact on Attention, Well-Being, and Inflammation.
TL;DR: An overview of the impact of mindfulness training on three areas of functioning in older adults: behavioral and neural correlates of attentional performance, psychological well-being, and systemic inflammation is provided.
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Longitudinal Evidence for Increased Functional Response in Frontal Cortex for Older Adults with Hippocampal Atrophy and Memory Decline
TL;DR: The functional organization of the frontal cortex is dynamic as mentioned in this paper, and age-related increases in frontal functional responses have been shown during various cognitive tasks, but the cross-sectional nature of the responses is unknown.
References
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Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
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Random-effects models for longitudinal data
Nan M. Laird,James H. Ware +1 more
TL;DR: In this article, a unified approach to fitting two-stage random-effects models, based on a combination of empirical Bayes and maximum likelihood estimation of model parameters and using the EM algorithm, is discussed.
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Mild Cognitive Impairment: Clinical Characterization and Outcome
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +5 more
TL;DR: Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
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The Adaptive Brain: Aging and Neurocognitive Scaffolding
TL;DR: The scaffolding theory of aging and cognition (STAC) is proposed, suggesting that pervasive increased frontal activation with age is a marker of an adaptive brain that engages in compensatory scaffolding in response to the challenges posed by declining neural structures and function.
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Aging gracefully: compensatory brain activity in high-performing older adults.
TL;DR: The results suggest that low- performing older adults recruited a similar network as young adults but used it inefficiently, whereas high-performing older adults counteracted age-related neural decline through a plastic reorganization of neurocognitive networks.