Journal ArticleDOI
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
TLDR
Recent evidence indicating that a parallel functional architecture may also be characteristic of the organization within each individual circuit is discussed, which represents a significant departure from earlier concepts of basal ganglia organization.About:
This article is published in Trends in Neurosciences.The article was published on 1990-07-01. It has received 4011 citations till now. The article focuses on the topics: Indirect pathway of movement & Direct pathway of movement.read more
Citations
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The neural basis of human error processing: Reinforcement learning, dopamine, and the error-related negativity.
TL;DR: This paper presented a unified account of two neural systems concerned with the development and expression of adaptive behaviors: a mesencephalic dopamine system for reinforcement learning and a generic error-processing system associated with the anterior cingulate cortex.
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The basal ganglia: focused selection and inhibition of competing motor programs.
TL;DR: The hypothesis states that the basal ganglia do not generate movements, and when voluntary movement is generated by cerebral cortical and cerebellar mechanisms, the basal Ganglia act broadly to inhibit competing motor mechanisms that would otherwise interfere with the desired movement.
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Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
André Parent,Lili-Naz Hazrati +1 more
TL;DR: The basal ganglia circuitry is designed so as to modulate in a precise manner the neuronal activity of several brain functional systems, which are involved in the direct control of different aspects of psychomotor behavior.
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Frontal-subcortical circuits and human behavior.
TL;DR: Frontal-subcortical circuits mediate many aspects of human behavior, including executive function deficits occur with lesions of the dorsolateral prefrontal circuit, disinhibition with injuries of the orbitofrontal circuit, and apathy with injury to the anterior cingulate circuit.
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Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Alexxai V. Kravitz,Benjamin S. Freeze,Philip R.L. Parker,Kenneth Kay,Myo T. Thwin,Karl Deisseroth,Anatol C. Kreitzer +6 more
TL;DR: These findings establish a critical role for basal ganglia circuitry in the bidirectional regulation of motor behaviour and indicate that modulation of direct-pathway circuitry may represent an effective therapeutic strategy for ameliorating parkinsonian motor deficits.
References
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Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex
TL;DR: The basal ganglia serve primarily to integrate diverse inputs from the entire cerebral cortex and to "funnel" these influences, via the ventrolateral thalamus, to the motor cortex.
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The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
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Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey
TL;DR: The present findings suggest a new conceptualization of corticostriatal topography in the primate which emphasizes the longitudinal arrangement of cortical terminal domains, and provide a map for functional parcellation of the neostriatum on the basis of its cortical innervation.
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The origin of thalamic inputs to the arcuate premotor and supplementary motor areas
GR Schell,Peter L. Strick +1 more
TL;DR: Karger et al. as mentioned in this paper used retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase to examine the origin of thalamic input to the two premotor areas with the densest projections to the motor cortex.
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Bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. An autoradiographic study in Macaca fascicularis.
TL;DR: By tracing radioactively labeled proteins transported by axonal flow, projections from area 4 to the ipsi- and contralateral neostriatum and claustrum were demonstrated in 7 monkeys, suggesting differential functions for the two striatal components in sensorimotor mechanisms.