Fungal biofilm resistance.
TLDR
The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.Abstract:
Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.read more
Citations
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Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
Janaina de Cássia Orlandi Sardi,Liliana Scorzoni,T Bernardi,A. M. Fusco-Almeida,M J S Mendes Giannini +4 more
TL;DR: A brief review of the literature regarding the epidemiology of Candida species, as well as their pathogenicity and ability to form biofilms, the antifungal activity of natural products and other therapeutic options is presented.
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Candida albicans Biofilms and Human Disease.
TL;DR: Current knowledge of biofilms formed by C. albicans and closely related fungal species are reviewed, finding that these biofilm-based infections are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental perturbations.
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The global problem of antifungal resistance: prevalence, mechanisms, and management
TL;DR: An effective antifungal stewardship programme is essential to control drug resistance, and should incorporate rapid fungal diagnostics, therapeutic drug monitoring, and clinical intervention teams.
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Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors
Bruna Gonçalves,Carina Sofia Vieira Ferreira,Carlos Alves,Mariana Henriques,Joana Azeredo,Sónia Carina Silva +5 more
TL;DR: Information about the current state of knowledge on the risk factors that predispose to VVC is provided, also including a revision of the epidemiology and microbiology of VVC, as well as of Candida virulence factors associated with vaginal pathogenicity.
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Mechanisms of Candida biofilm drug resistance
TL;DR: The molecular mechanisms underlying Candida biofilm antifungal resistance are reviewed and their relative contributions during various growth phases are reviewed.
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