Journal ArticleDOI
Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products
TLDR
This overview will highlight the chemical potential of endophytic fungi with focus on the detection of pharmaceutically valuable plant constituents, e.g. paclitaxel, camptothecin and podophyllotoxin, as products of fungal biosynthesis, and new bioactive metabolites reported in recent years from fungal endophytes of terrestrial and mangrove plants.Abstract:
Bioactive natural products from endophytic fungi, isolated from higher plants, are attracting considerable attention from natural product chemists and biologists alike as indicated by the steady increase of publications devoted to this topic during recent years (113 research articles on secondary metabolites from endophytic fungi in the period of 2008–2009, 69 in 2006–2007, 36 in 2004–2005, 14 in 2002–2003, and 18 in 2000–2001). This overview will highlight the chemical potential of endophytic fungi with focus on the detection of pharmaceutically valuable plant constituents, e.g. paclitaxel, camptothecin and podophyllotoxin, as products of fungal biosynthesis. In addition, it will cover new bioactive metabolites reported in recent years (2008–2009) from fungal endophytes of terrestrial and mangrove plants. The presented compounds are selected based on their antimicrobial, antiparasitic, cytotoxic as well as neuroprotective activities. Furthermore, possible factors influencing natural product production in endophytes cultivated in vitro and hence the success of bioprospecting from endophytes are likewise discussed in this review.read more
Citations
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Journal ArticleDOI
The Hidden World within Plants: Ecological and Evolutionary Considerations for Defining Functioning of Microbial Endophytes
Pablo R. Hardoim,Leonard S. van Overbeek,Gabriele Berg,Anna Maria Pirttilä,Stéphane Compant,Andrea Campisano,Matthias Döring,Angela Sessitsch +7 more
TL;DR: This review addresses the concept of endophytism, considering the latest insights into evolution, plant ecosystem functioning, and multipartite interactions.
Journal ArticleDOI
Chemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites
TL;DR: The possible current and future strategies of understanding the chemical communication of endophytic fungi with other endophytes and with their host plants might not only allow the discovery and sustainable production of desirable natural products but also other mostly overlooked bioactive secondary metabolites.
Journal ArticleDOI
Fungal endophytes: unique plant inhabitants with great promises
TL;DR: The chemical potential of endophytic fungi for drug discovery will be discussed with focus on the detection of pharmaceutically valuable plant constituents as products of fungal biosynthesis.
Journal ArticleDOI
Bacterial endophyte Sphingomonas sp. LK11 produces gibberellins and IAA and promotes tomato plant growth
Abdul Latif Khan,Muhammad Waqas,Sang-Mo Kang,Ahmed Al-Harrasi,Javid Hussain,Ahmed Al-Rawahi,Salima Al-Khiziri,Ihsan Ullah,Liaqat Ali,Hee-Young Jung,In-Jung Lee +10 more
TL;DR: Tomato plants inoculated with endophytic Sphingomonas sp.
Journal ArticleDOI
The genus Phomopsis: biology, applications, species concepts and names of common phytopathogens
Dhanushka Udayanga,Dhanushka Udayanga,Xingzhong Liu,Eric H. C. McKenzie,Ekachai Chukeatirote,Ali H. Bahkali,Kevin D. Hyde,Kevin D. Hyde +7 more
TL;DR: An overview of the current status of the taxonomy in Phomopsis with special reference to biology, applications of various species, species concepts, future research perspectives and names of common pathogens is provided.
References
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Journal ArticleDOI
Bioprospecting for Microbial Endophytes and Their Natural Products
Gary A. Strobel,Bryn Daisy +1 more
TL;DR: Endophytic microorganisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic, which may produce a plethora of substances of potential use to modern medicine, agriculture, and industry.
Journal ArticleDOI
Taxol and Taxane Production by Taxomyces andreanae, an Endophytic Fungus of Pacific Yew
TL;DR: Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia, and taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol.
Journal ArticleDOI
Endophytes: a rich source of functional metabolites.
Ren-Xiang Tan,W. X. Zou +1 more
Journal ArticleDOI
Natural products from endophytic microorganisms.
TL;DR: The prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great and other applications in industry and agriculture may also be discovered among the novel products produced by endophytic microbes.
Journal ArticleDOI
Fungal endophytes limit pathogen damage in a tropical tree
A. Elizabeth Arnold,Luis C. Mejía,Damond Kyllo,Enith I. Rojas,Zuleyka Maynard,Nancy Robbins,Edward Allen Herre +6 more
TL;DR: It is shown that inoculation of endophyte-free leaves with endophytes isolated frequently from naturally infected, asymptomatic hosts significantly decreases both leaf necrosis and leaf mortality when T. cacao seedlings are challenged with a major pathogen.
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Bioprospecting for Microbial Endophytes and Their Natural Products
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