G-quadruplex: Flexible conformational changes by cations, pH, crowding and its applications to biosensing.
TLDR
In this article, the effects of surrounding conditions (e.g., metal cations, pH, and crowding) on G-quadruplex conformations and the application of G4s mainly in biosensor fields, and in others.About:
This article is published in Biosensors and Bioelectronics.The article was published on 2021-04-15 and is currently open access. It has received 42 citations till now.read more
Citations
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Nanomaterial-Based Label-Free Electrochemical Aptasensors for the Detection of Thrombin
TL;DR: In this article , the most recent advances in label-free electrochemical aptasensors for thrombin detection, with an emphasis on nanomaterials and nanostructures utilized in sensor design and fabrication, are summarized and compared according to their material structures and compositions.
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Recent Developments in G-Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes.
TL;DR: The latest applications of G-quadruplex structures as detectors of genome-wide, enantioselective catalysts, disease therapeutics, promising drug targets, and smart fluorescence probes are summarized.
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Inhibition of CRISPR-Cas12a trans-cleavage by lead (II)-induced G-quadruplex and its analytical application
TL;DR: In this article , the authors proposed a new method for detecting Pb2+ based on its induced G-quadruplex inhibition on CRISPR-Cas12a trans-cleavage.
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Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure.
Valeria Libera,Valeria Libera,Elena A. Andreeva,Anne Martel,Aurelien Thureau,M. Longo,Caterina Petrillo,Alessandro Paciaroni,Giorgio Schirò,Lucia Comez +9 more
TL;DR: In this article, a structure-based strategy, integrating complementary probes, was employed to study the interaction between TMPyP4 porphyrin and a 22-base human telomeric sequence (Tel22) before and after irradiation with blue light.
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An aptasensor for the detection of Pb2+ based on photoinduced electron transfer between a G-quadruplex-hemin complex and a fluorophore.
TL;DR: In this paper, a fluorescent aptasensor was developed for the 'turn-off' model detection of Pb2+, where the dye-labeled nucleic acid strand can be folded into a G-quadruplex structure.
References
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Journal ArticleDOI
Selection of single-stranded DNA molecules that bind and inhibit human thrombin.
TL;DR: The isolation of single-stranded DNA aptamers to the protease thrombin of the blood coagulation cascade is described and binding affinities in the range 25–200 nM are reported.
Journal ArticleDOI
Crystal structure of parallel quadruplexes from human telomeric DNA.
TL;DR: This crystal structure of a quadruplex formed from four consecutive human telomeric DNA repeats and grown at a K+ concentration that approximates its intracellular concentration suggests a straightforward path for telomere folding and unfolding, as well as ways in which it can recognize telomerre-associated proteins.
Journal ArticleDOI
Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis
Dipankar Sen,Walter Gilbert +1 more
TL;DR: It is speculated that this self-recognition of guanine-rich motifs of DNA serves to bring together, and to zipper up in register, the four homologous chromatids during meiosis.
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The footprint of urban heat island effect in China
TL;DR: Using MODIS data from 2003 to 2012, it is shown that the UHI effect decayed exponentially toward rural areas for majority of the 32 Chinese cities, and an obvious urban/rural temperature “cliff” is found.
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Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex
TL;DR: The availability of the d[AG3(T2AG3)3] solution structure containing four AG3 human telomeric repeats should permit the rational design of ligands that recognize and bind with specificity and affinity to the individual grooves of the G-tetraplex, as well as to either end containing the diagonal and lateral loops.
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