Gadolinium-containing magnetic resonance image contrast agent promotes fibrocyte differentiation.
Varsha Vakil,Joanna J. Sung,Marta Piecychna,Jeffrey R. Crawford,Phillip H. Kuo,Ali K. Abu-Alfa,Shawn E. Cowper,Richard Bucala,Richard H. Gomer +8 more
TLDR
The data suggest that Omniscan interferes with the regulatory action of signals that inhibit the differentiation of monocytes to fibrocytes, and this effect does not require the presence of other cells (such as T cells) in the PBMCs.Abstract:
Gadolinium-containing magnetic resonance imaging (MRI) contrast agents such as Omniscan are associated with nephrogenic systemic fibrosis (NSF). To determine if Omniscan can affect the differentiation of monocytes into fibroblast-like cells called fibrocytes that are found in the fibrotic lesions of NSF, peripheral blood mononuclear cells (PBMCs) from NSF patients, hemodialysis patients without NSF, and healthy, renally sufficient controls were exposed to Omniscan in a standardized in vitro fibrocyte differentiation protocol. When added to PBMCs, the gadolinium-containing MRI contrast agent Omniscan generally had little effect on fibrocyte differentiation. However, 10(-8) to 10(-3) mg/mL Omniscan reduced the ability of the fibrocyte differentiation inhibitor serum amyloid P (SAP) to decrease fibrocyte differentiation in PBMCs from 15 of 17 healthy controls and one of three NSF patients. Omniscan reduced the ability of SAP to decrease fibrocyte differentiation from purified monocytes, indicating that the Omniscan effect does not require the presence of other cells (such as T cells) in the PBMCs. Omniscan also reduced the ability of a different fibrocyte differentiation inhibitor, interleukin-12, to decrease fibrocyte differentiation. These data suggest that Omniscan interferes with the regulatory action of signals that inhibit the differentiation of monocytes to fibrocytes. J. Magn. Reson. Imaging 2009;30:1284-1288. (c) 2009 Wiley-Liss, Inc.read more
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Journal ArticleDOI
Fibrocytes: emerging effector cells in chronic inflammation
TL;DR: The immunological mediators controlling fibrocyte differentiation and recruitment are described, the association of fibroCytes with chronic inflammatory diseases is described and the potential roles of Fibrocytes in these disorders with those of macrophages and fibroblasts are compared.
Book
Fibrocytes in Health and Disease
Adriana Blakaj,Richard Bucala +1 more
TL;DR: New developments in the cellular and molecular biology of fibrocytes are integrated with current concepts regarding the etiopathogenesis of fibrosing disorders to suggest new opportunities for therapeutic manipulation of these cells in fibrogenesis.
Journal ArticleDOI
Fibrocytes in health and disease
Erica L. Herzog,Richard Bucala +1 more
TL;DR: Fibrocytes are circulating mesenchymal progenitor cells that participate in tissue responses to injury and invasion as discussed by the authors, and they are a biomarker for disease progression in chronic lung diseases including asthma and pulmonary fibrosis.
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Surface interactions with compartmentalized cellular phosphates explain rare earth oxide nanoparticle hazard and provide opportunities for safer design.
Ruibin Li,Zhaoxia Ji,Chong Hyun Chang,Darren R. Dunphy,Xiaoming Cai,Huan Meng,Haiyuan Zhang,Bingbing Sun,Xiang Wang,Juyao Dong,Sijie Lin,Meiying Wang,Yu-Pei Liao,C. Jeffrey Brinker,Andre E. Nel,Andre E. Nel,Tian Xia,Tian Xia +17 more
TL;DR: A mechanistic understanding of how REOs induce cellular and pulmonary damage by a compartmentalized intracellular biotransformation process in lysosomes that results in pro-fibrogenic growth factor production and lung fibrosis is obtained.
Journal ArticleDOI
Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype.
Susan K. Mathai,Mridu Gulati,Xueyan Peng,Thomas Russell,Albert C. Shaw,Ami N. Rubinowitz,Lynne Murray,Jonathan M. Siner,Danielle Antin-Ozerkis,Ruth R. Montgomery,Ronald Reilkoff,Richard Bucala,Erica L. Herzog +12 more
TL;DR: The data indicate that the blood of patients with SSc-ILD and of healthy aged controls is enriched for fibrocytes, profibrotic monocytes, and fibrosis-associated mediators.
References
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Journal Article
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