Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study.
Yuji Shimizu,Shin-ya Kawashiri,Kairi Kiyoura,Kenichi Nobusue,Hirotomo Yamanashi,Yasuhiro Nagata,Takahiro Maeda +6 more
TLDR
γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis, which means active endothelial repair that is associated with Atherosclerosis might have beneficial association with pulmonary arterial hypertension.Abstract:
Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted. We conducted a cross-sectional study of 562 elderly Japanese men aged 60–69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension. In the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)). γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.read more
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Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study.
Yuji Shimizu,Shin-ya Kawashiri,Kairi Kiyoura,Jun Koyamatsu,Shoichi Fukui,Mami Tamai,Kenichi Nobusue,Hirotomo Yamanashi,Yasuhiro Nagata,Takahiro Maeda +9 more
TL;DR: Circulating CD34+ cells are positively associated with active arterial wall thickening in subjects without hypertension, and this study demonstrates a means to clarify the mechanisms of endothelial repair in elderly subjects.
Journal ArticleDOI
Influence of height on endothelial maintenance activity: a narrative review
Yuji Shimizu,Takahiro Maeda +1 more
TL;DR: In this article, the background mechanism of the inverse association between height and cardiovascular disease has not yet been clarified, and the anthropological reasons behind the high risk of atherosclerosis progression in Japanese individuals with acquired genetic characteristics are discussed.
Journal ArticleDOI
Vascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension
Yuji Shimizu,Kazuhiko Arima,Yuko Noguchi,Hirotomo Yamanashi,Shin-ya Kawashiri,Kenichi Nobusue,Fumiaki Nonaka,Kiyoshi Aoyagi,Yasuhiro Nagata,Takahiro Maeda +9 more
TL;DR: In this article , a cross-sectional study of 1793 older Japanese adults aged 60-89 years with hypertension who participated in general health check-ups was conducted and the angiogenesis-related polymorphism rs3025039 was associated with the development of atherosclerosis among older Japanese individuals.
Journal ArticleDOI
Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study.
Yuji Shimizu,Yuko Nabeshima-Kimura,Shin-ya Kawashiri,Yuko Noguchi,Yasuhiro Nagata,Takahiro Maeda,Naomi Hayashida +6 more
TL;DR: TSH is positively associated with hypertension only in individuals without thyroid cysts, and the correlation between the TSH and free triiodothyronine (fee T3) levels was stronger in the subjects without thyroidCysts than in those with thyroid Cysts.
Journal ArticleDOI
Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population.
Yuji Shimizu,Kazuhiko Arima,Yuko Noguchi,Shin-ya Kawashiri,Hirotomo Yamanashi,Mami Tamai,Yasuhiro Nagata,Takahiro Maeda +7 more
TL;DR: Hematopoietic activity evaluated by reticulocytes levels could influence on the association between single nucleotide polymorphism (rs3782886 and rs671) and hypertension, and results were efficient tool to clarify the part of the mechanism that underlying the link between genetic factor and hypertension.
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