Journal ArticleDOI
Gap detection deficits in rats with tinnitus: A potential novel screening tool.
Jeremy G. Turner,Thomas J. Brozoski,Carol A. Bauer,Jennifer L. Parrish,Kristin S. Myers,Larry F. Hughes,Donald M. Caspary +6 more
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TLDR
It is suggested that gap detection reflex procedures might be effective for rapid tinnitus screening in rats when the gap was embedded in a background similar to their tinnitis.Abstract:
The study describes a novel method for tinnitus screening in rats by use of gap detection reflex procedures. The authors hypothesized that if a background acoustic signal was qualitatively similar to the rat's tinnitus, poorer detection of a silent gap in the background would be expected. Rats with prior evidence of tinnitus at 10 kHz (n = 14) exhibited significantly worse gap detection than controls (n = 13) when the gap was embedded in a background similar to their tinnitus. No differences between tinnitus and control rats were found with 16 kHz or broadband noise backgrounds, which helped to rule out explanations related to hearing loss or general performance deficits. The results suggest that gap detection reflex procedures might be effective for rapid tinnitus screening in rats.read more
Citations
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Tuning out the noise: limbic-auditory interactions in tinnitus.
TL;DR: A testable model for tinnitus is proposed that is grounded in recent findings from human imaging and focuses on brain areas in cortex, thalamus, and ventral striatum and aims to enable the development of effective treatment.
Journal ArticleDOI
Reversing pathological neural activity using targeted plasticity
Jonathan Riley,Jonathan D. Seale,William A. Vrana,Jai Shetake,Sindhu P. Sudanagunta,Michael S. Borland,Michael P. Kilgard +6 more
TL;DR: Evidence is reported that reversing the brain changes responsible can eliminate the perceptual impairment in an animal model of noise-induced tinnitus and this method for restoring neural activity to normal may be applicable to a variety of neurological disorders.
Journal ArticleDOI
Tinnitus: causes and clinical management
TL;DR: Assessment of patients includes a detailed case history, measurement of hearing function, quantification of tinnitus severity, and identification of causal factors, associated symptoms, and comorbidities.
Journal ArticleDOI
Maladaptive plasticity in tinnitus--triggers, mechanisms and treatment.
TL;DR: This Review highlights the links between animal and human studies, and discusses several therapeutic approaches that have been developed to target the neuroplastic changes underlying tinnitus.
Journal ArticleDOI
Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?
TL;DR: A role for cochlear primary neuronal degeneration, per se, in the central neural excitability that could underlie the generation of hyperacusis is suggested.
References
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TL;DR: A review of the literature on prepulse inhibition (PPI) in humans can be found in this article, where a relatively weak sensory event (the prepulse) is presented 30-500 ms before a strong startle-inducing stimulus, and reduces the magnitude of the startle response.
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Howard S. Hoffman,James R. Ison +1 more
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TL;DR: The ASR may be a valuable model for the study of general principles of sensorimotor-motivational information processing at the behavioral and neurophysiological level in mammals.