Open AccessJournal Article
Gastrointestinal stromal tumor (GIST) with glandular component. A report of an unusual tumor resembling adenosarcoma
TLDR
A collision of GIST and gastritis cystica profunda is suggested in the histogenesis of the lesion.Abstract:
A case of gastrointestinal stromal tumor (GIST) with an unusual glandular component is reported. The tumor was found in the gastric fundus of a 93-year-old woman. Histologically, the lesion showed a biphasic adenosarcoma-like structure. Typical low-grade spindle cell patterns of GIST were intermingled with numerous and partly cystic glands. The glandular epithelium had pyloric/foveolar-like appearance, with foci of intestinal metaplasia and low-grade dysplasia. The stromal component was immunoreactive for CD117 (c-kit) and CD34, and negative for myoid and neuroid markers. The ultrastructural examination found nondescript and undifferentiated spindle cells. The gastric mucosa and submucosa near the tumor contained a small area with features of gastritis cystica profunda, with glands similar to those present inside the tumor. Therefore, a collision of GIST and gastritis cystica profunda is suggested in the histogenesis of the lesion.read more
Citations
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Journal ArticleDOI
Gastrointestinal stromal tumors: diagnostic challenges and practical approach to differential diagnosis.
TL;DR: The purpose of this review is to provide an update of the expanding differential diagnosis of GISTS, to draw attention to unusual GIST variants, and to highlight some of the challenges faced by pathologists in resolving this differential diagnosis.
Journal ArticleDOI
Gastrointestinal stromal tumor and gastric adenocarcinoma collision tumors
TL;DR: It is hypothesize that development of gastric adenocarcinoma within a gastrointestinal stromal tumor may be based on displaced gastric epithelium in a long-standing stromaal tumor with events of intermittent ulceration and epithelial regeneration.
Journal ArticleDOI
Gastric adenocarcinoma appearance in leiomyoma: A case report.
Kaoru Wada,Hirofumi Tazawa,Toshiaki Komo,Naoto Hadano,Takashi Onoe,Takeshi Sudo,Yosuke Shimizu,Kazuya Kuraoka,Takahisa Suzuki,Hirotaka Tashiro +9 more
TL;DR: This is the first report that describes a case of gastric adenocarcinoma arising from a leiomyoma, which is diagnosed by pathological evidence as heterotopic glands carcinoma within it.
References
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Journal ArticleDOI
Diagnosis of gastrointestinal stromal tumors: A consensus approach.
Christopher D.M. Fletcher,Jules J. Berman,Christopher L. Corless,Fred Gorstein,Jerzy Lasota,B. Jack Longley,Markku Miettinen,Timothy J. O'Leary,Helen Remotti,Brian P. Rubin,Barry M. Shmookler,Leslie H. Sobin,Sharon W. Weiss +12 more
TL;DR: Key elements of the consensus are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term "benign" for any GIST, at least at the present time.
Journal Article
Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal.
TL;DR: It is concluded that gastrointestinal stromal tumors show striking morphological and immunophenotypic similarities with ICC and that they may originate from stem cells that differentiate toward a pacemaker cell phenotype and it is proposed that the noncommittal name "gastrointestinal stromic tumor" be replaced by gastrointestinal pacemaker Cell tumor.
Journal ArticleDOI
Gastric stromal tumors. Reappraisal of histogenesis.
Michael T. Mazur,H. Clark +1 more
TL;DR: The results of this study indicate that many gastric wall tumors are not derived from smooth muscle, and suggests that the myenteric nervous system is a possible source for perineurial or mesenchymal nerve sheath cells with distinctive fine structure.
Journal Article
CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34
TL;DR: Results indicate that CD117 is a specific marker for GIST among tumors that occur in the GI tract and adjacent regions, and separates GISTs from true leiomyomas and gastric schwannomas.
Journal ArticleDOI
Gastrointestinal stromal tumors--value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas
TL;DR: It is shown that gastrointestinal mesenchymal tumors can be immunophenotypically divided in categories that correlate with light microscopically defined diagnostic entities, namely typical leiomyomas, schwannomas, and GIST, most cases of the latter representing tumors of primitive meschymal cells that are CD34 positive.
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