Journal ArticleDOI
Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression.
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TLDR
Results suggest that the gonadal hormone milieu of the animal plays a role in modulating sucrose preference and activity levels following OBX, a well-documented animal model of depression.Abstract:
Major depressive disorder (MDD) affects women to a greater extent then men; however, the few studies that have examined the role of gender in an animal model of depression have shown inconsistent results. The purpose of the present study was to determine if the gonadal hormone milieu of the animal modulated behavioral changes following olfactory bulbectomy (OBX), a well-documented animal model of depression. Body weight, sucrose preference levels and open-field activity levels were measured once a week for a period of 2 weeks in gonadally intact and gonadectomized male and female rats. Following these baseline measurements, animals underwent either OBX or sham surgery. Body weight, sucrose preference and activity levels were assessed for 4 weeks post-OBX surgery. OBX-gonadectomized animals exhibited higher activity levels than OBX gonadally intact and control animals. This effect of gonadectomy was more robust in males. OBX-females (both intact and gonadectomized) exhibited significantly lower sucrose preference levels than OBX-males (both intact and gonadectomized) and control animals. These results suggest that the gonadal hormone milieu of the animal plays a role in modulating sucrose preference and activity levels following OBX.read more
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Journal ArticleDOI
The olfactory bulbectomised rat as a model of depression
Cai Song,Brian E. Leonard +1 more
TL;DR: The olfactory bulbectomized rat is not only a model for detecting antidepressant activity but also one for exploring the inter-relationships between these systems that are also dysfunctional in patients with major depression.
Journal ArticleDOI
In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice.
John F. Cryan,Cedric Mombereau +1 more
TL;DR: It is suggested that it is prudent and most appropriate to use convergent tests that draw on different antidepressant-related endophenotypes, and complimentary physiological analyses in order to provide a program of information concerning whether a given phenotype is functionally relevant to depression-related pathology.
Journal ArticleDOI
The validity of animal models of predisposition to depression.
Paul Willner,P J Mitchell +1 more
TL;DR: This paper reviews the validity of the available models of predisposition to depression, which derive from genetics, genomics, developmental manipulations, and brain lesioning, and compares the performance of the different models using a novel scoring system.
Book ChapterDOI
Animal models of psychiatric disorders.
TL;DR: Animal models of depression, anxiety, schizophrenia, or addiction remain a key heuristic approach to elucidation of the pathophysiology and treatment of psychiatric disorders.
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Journal ArticleDOI
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Journal ArticleDOI
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