Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Michael J. Seckl,Neil J. Sebire,Rosemary A. Fisher,François Golfier,Leon F.A.G. Massuger,C. Sessa +5 more
TLDR
This work presents a meta-analysis of 129 cases of central giant cell granuloma in mice over a 12-month period and shows clear trends in prognosis, disease progression, and mortality that are consistent with those of animals treated with chemotherapy.About:
This article is published in Annals of Oncology.The article was published on 2013-10-01 and is currently open access. It has received 289 citations till now. The article focuses on the topics: Gestational trophoblastic disease & Choriocarcinoma.read more
Citations
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Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers.
TL;DR: An overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy is taken.
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Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup.
Giorgia Mangili,Domenica Lorusso,Jubilee Brown,Jacobus Pfisterer,Leon F.A.G. Massuger,Michelle D. Vaughan,Hextan Y.S. Ngan,François Golfier,Paradan K. Sekharan,Rafael Cortés Charry,Andres Poveda,Jae Weon Kim,Y. Xiang,Ross S. Berkowtiz,Michael J. Seckl +14 more
TL;DR: A consensus review on gestational trophoblastic disease diagnosis and management from the combined International Society for the Study of Trophoblastics Disease, European Organisation for the Treatment of TroPHoblastic Disease, and the Gynecologic Cancer InterGroup is provided.
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Gestational Trophoblastic Disease: Clinical and Imaging Features
Akram M. Shaaban,Maryam Rezvani,Reham R. Haroun,Anne Kennedy,Khaled M. Elsayes,Jeffrey Dee Olpin,Mohamed E. Salama,Bryan R. Foster,Christine O. Menias +8 more
TL;DR: While GTN after a molar pregnancy is usually diagnosed with serial β-hCG titers, imaging plays an important role in evaluation of local extent of disease and systemic surveillance.
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15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage.
TL;DR: Improvements in treatment and the understanding of gestational trophoblastic neoplasia have resulted in changes in staging, advances in treatment options, and opportunities for fertility preservation.
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Gestational Trophoblastic Tumours: An Update for 2014
TL;DR: A general overview of gestational trophoblastic disease, the most recent insights in aetiology and pathology and a summary of the different management strategies are given.
References
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Gestational trophoblastic disease
TL;DR: Patients diagnosed with molar pregnancy are treated by either suction curettage or hysterectomy, depending on their desire to preserve fertility, and patients who have metastatic disease are treated primarily with combination chemotherapy and, as indicated, adjuvant radiotherapy or surgery.
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Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.
Ie Ming Shih,Robert J. Kurman +1 more
TL;DR: It appears that ETT develops from neoplastic transformation of chorionic-type intermediate trophoblast, a rare trophoblastic tumor that simulates carcinoma and can behave in a malignant fashion.
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Gestational Trophoblastic Disease
TL;DR: In this paper, a hysterectomy was performed in all cases of placental-site trophoblastic tumors; combination chemotherapy was used if there was evidence of metastatic disease.
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EMA/CO for high-risk gestational trophoblastic tumors: results from a cohort of 272 patients.
Mark Bower,Edward S. Newlands,L. Holden,D Short,Cathryn S Brock,G.J.S. Rustin,R. H. J. Begent,Kd Bagshawe +7 more
TL;DR: EMA/CO is an effective and well-tolerated regimen for high-risk GTT and more than half of the women will retain their fertility; however, there is a small but significant risk of second malignancy.
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Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin
Neil J. Sebire,Marianne Foskett,F. J. Paradinas,Rosemary A. Fisher,Ros J Francis,D Short,Edward S. Newlands,Michael J. Seckl +7 more
TL;DR: CHM and healthy co-twin pregnancies have a high risk of spontaneous abortion, but about 40% result in livebirths, without significantly increasing the risk of pGTD.