Journal ArticleDOI
Giant Cell–Containing Tumors of Bone
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TLDR
The range of neoplastic and nonneoplastic lesions, which histologically contain numerous osteoclastic giant cells, is considered, and several lesions that frequently enter into the differential diagnosis are focused on.About:
This article is published in Surgical Pathology Clinics.The article was published on 2017-09-01. It has received 14 citations till now. The article focuses on the topics: Giant Cell Tumors & Giant cell.read more
Citations
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Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy.
Inga-Marie Schaefer,Jonathan A. Fletcher,G. Petur Nielsen,Angela R. Shih,Marco Ferrone,Jason L. Hornick,Xiaohua Qian +6 more
TL;DR: The objective of the current study was to validate H3G34W and H3K36M IHC in the diagnosis of giant cell‐rich bone tumors on fine‐needle aspiration and core needle biopsy specimens.
Journal ArticleDOI
Role of cancer stem cells in the development of giant cell tumor of bone
Abdul Rouf War,Kai Dang,Shanfen Jiang,Zhongwei Xiao,Zhiping Miao,Tuanmin Yang,Yu Li,Airong Qian +7 more
TL;DR: The role played by cancer stem cells involving certain important molecules/factors such as, Mesenchymal Stem Cells (MSCs), miRNAs and signaling mechanism such as; mTOR/PI3K-AKT, towards the formation of giant cell tumor of bone is summarized to get an insight regarding various effective strategies and research advancements.
Journal ArticleDOI
Giant Cell Tumor of Bone With Cartilage Matrix: A Clinicopathologic Study of 17 Cases.
Iva Brcic,Feisal Yamani,Carrie Y. Inwards,Vaiyapuri Sumathi,Leslie G. Dodd,Portia A. Kreiger,Kesavan Sittampalam,Ted R Allred,Karl Kashofer,Bernadette Liegl-Atzwanger,Darcy A. Kerr,Darcy A. Kerr,Gunnlaugur P. Nielsen,Andrew E. Rosenberg +13 more
TL;DR: The cartilage matrix is associated with woven bone suggesting the neoplastic cells may differentiate into chondrocyte-like and osteoblast-like cells, and recognition of this neoplasm is important to prevent misdiagnosis and overtreatment of affected patients.
Journal ArticleDOI
Updates in Primary Bone Tumors: Current Challenges and New Opportunities in Cytopathology.
TL;DR: The review summarizes the current diagnostic challenges in fine-needle aspiration of primary bone tumors, with focus on the application of new molecular and immunohistochemical techniques in the diagnosis of giant cell-rich neoplasms, chondrosarcomas, and notochordal tumors.
Journal ArticleDOI
Examining variation in skeletal tuberculosis in a late pre-contact population from the eastern mountains of Peru.
TL;DR: Variation in lesion distribution in this population-based study shows the importance of identifying extra-vertebral tuberculosis and suggests that the disease may have manifested differently than at other coastal sites.
References
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Journal ArticleDOI
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
Sam Behjati,Sam Behjati,Patrick S. Tarpey,Nadege Presneau,Susanne Scheipl,Susanne Scheipl,Nischalan Pillay,Nischalan Pillay,Peter Van Loo,Peter Van Loo,David C. Wedge,Susanna L. Cooke,Gunes Gundem,Helen Davies,Serena Nik-Zainal,Sancha Martin,Stuart McLaren,Victoria Goodie,Ben Robinson,Adam Butler,Jon W. Teague,Dina Halai,Bhavisha Khatri,Ola Myklebost,Daniel Baumhoer,Gernot Jundt,Rifat Hamoudi,Roberto Tirabosco,M Fernanda Amary,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell,Adrienne M. Flanagan,Adrienne M. Flanagan +34 more
TL;DR: A remarkable picture of tumor type specificity for histone H 3.3.3 driver alterations emerges, indicating that hist one H3.
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USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts.
Andre M. Oliveira,Andre M. Oliveira,Antonio R. Perez-Atayde,Carrie Y. Inwards,Fabiola Medeiros,Victoria Derr,Bae Li Hsi,Mark C. Gebhardt,Andrew E. Rosenberg,Jonathan A. Fletcher,Jonathan A. Fletcher +10 more
TL;DR: It is demonstrated that primary ABC are mesenchymal neoplasms exhibiting USP6 and/or CDH11 oncogenic rearrangements, and although morphological mimics of primary ABC, appear to represent a non-specific morphological pattern of a diverse group of non-ABC neoplasm.
Journal ArticleDOI
Giant-cell tumour of bone.
TL;DR: Giant cell tumour (GCT) is still one of the most obscure and intensively examined tumours of bone; and there are still many unanswered questions with regard to both its treatment and prognosis.
Journal ArticleDOI
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis.
Rikhia Chakraborty,Oliver A. Hampton,Xiaoyun Shen,Stephen J. Simko,Albert Shih,Harshal Abhyankar,Karen Phaik Har Lim,Kyle R. Covington,Lisa R. Trevino,Ninad Dewal,Donna M. Muzny,Harshavardhan Doddapaneni,Jianhong Hu,Linghua Wang,Philip J. Lupo,M. John Hicks,M. John Hicks,Diana L. Bonilla,Karen C. Dwyer,Marie-Luise Berres,Poulikos I. Poulikakos,Miriam Merad,Kenneth L. McClain,David A. Wheeler,Carl E. Allen,D. Williams Parsons +25 more
TL;DR: A model in which ERK activation is a universal end point in LCH arising from pathological activation of upstream signaling proteins is supported.
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USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst
Andre M. Oliveira,Andre M. Oliveira,Bae Li Hsi,Stanislawa Weremowicz,Andrew E. Rosenberg,Paola Dal Cin,Nora E. Joseph,Julia A. Bridge,Antonio R. Perez-Atayde,Jonathan A. Fletcher +9 more
TL;DR: It is shown that a recurring ABC chromosomal translocation t(16;17)(q22;p13) creates a fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence on 17p13.