Journal ArticleDOI
Glutathione as an oral whitening agent: A randomized, double-blind, placebo-controlled study
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TLDR
Oral glutathione administration results in a lightening of skin color in a small number of subjects, however, long-term safety has not been established and warrants more extensive clinical trials.Abstract:
Objective: To determine whether orally administered glutathione, 500 mg per day for 4 weeks, affects the skin melanin index, when compared with placebo. Methods: This randomized, double-blind, two-arm, placebo-controlled study was set in the King Chulalongkorn Memorial Hospital, Bangkok, Thailand, a teaching hospital affiliated with a medical school. Sixty otherwise healthy medical students were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks. The main outcome was mean reduction of melanin indices measured at six different sites. Several secondary outcomes, including UV spots, were recorded by VISIA™. Efficacies of glutathione and placebo were compared by ANCOVA with baseline values as co-variates. Results: Sixty participants enrolled and completed the study. At 4 weeks, the melanin indices decreased consistently at all six sites in subjects who received glutathione. The reductions were statistically significantly greater than those recei...read more
Citations
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Melasma: an Up-to-Date Comprehensive Review.
TL;DR: This review serves as a comprehensive update on the current understanding of the epidemiology, pathogenesis, clinical and histologic features of melasma, as well as treatments for this common, yet therapeutically challenging, condition.
Journal ArticleDOI
Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up
Fan Liu,Mijke Visser,David L. Duffy,Pirro G. Hysi,Leonie C. Jacobs,Oscar Lao,Kaiyin Zhong,Susan Walsh,Susan Walsh,Lakshmi Chaitanya,Andreas Wollstein,Andreas Wollstein,Gu Zhu,Grant W. Montgomery,Anjali K. Henders,Massimo Mangino,Daniel Glass,Veronique Bataille,Richard A. Sturm,Fernando Rivadeneira,Albert Hofman,Wilfred F. J. van IJcken,André G. Uitterlinden,Robert-Jan Palstra,Tim D. Spector,Nicholas G. Martin,Tamar Nijsten,Manfred Kayser +27 more
TL;DR: In this article, the authors investigated the genetics of human skin color by combining a series of genome-wide association studies (GWAS) in a total of 17,262 Europeans with functional follow-up of discovered loci.
Journal ArticleDOI
Oral tranexamic acid enhances the efficacy of low-fluence 1064-nm quality-switched neodymium-doped yttrium aluminum garnet laser treatment for melasma in Koreans: a randomized, prospective trial.
TL;DR: Oral TA may prove a safe and efficient treatment option for melasma in combination with low‐fluence QSNY laser therapy, and a greater number of patients scored as grade 3 and more in the combination group.
Journal ArticleDOI
Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners
TL;DR: Insight is provided into the mechanisms involved in melanin synthesis and the biological assays available to attest the lightening activity of individual ingredients and the legislation dealing with the use of skin lighteners is discussed.
Journal ArticleDOI
Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women
TL;DR: Topical G SSG is safe and effectively whitens the skin and improves skin condition in healthy women and there were no marked adverse effects from GSSG application.
References
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TL;DR: This work has shown that both transcriptional and post‐transcriptional mechanisms modulate the activity of this critical cellular enzyme, glutathione, in a tightly regulated manner in mammalian cells.
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Human skin pigmentation: melanocytes modulate skin color in response to stress
TL;DR: This review provides an updated overview of important physiological and biological factors that increase pigmentation and the mechanisms by which they do so and considers endo‐crine factors that induce temporary or permanent changes in skin color.
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Chemical and Instrumental Approaches to Treat Hyperpigmentation
TL;DR: This review describes the different approaches to obtain depigmentation, suggests a classification of whitening molecules on the basis of the mechanism by which they interfere with melanogenesis, and confirms the necessity to apply standardized protocols to evaluate depigmenting treatments.
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Autocrine and Paracrine Regulation of Melanocytes in Human Skin and in Pigmentary Disorders
TL;DR: The unveiled regulatory mechanisms involved in the abnormal up- or down-regulated levels of lesional melanocyte function provide new insights into therapeutic tools utilizing blockage of responsible cytokine networks.
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The systemic availability of oral glutathione.
TL;DR: It is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutATHione, suggesting that the systemic availability of glutathion is negligible in man.