Journal ArticleDOI
Glutathione : new candidate neuropeptide in the central nervous system
N. Guo,C. McIntosh,C. Shaw +2 more
TLDR
The localization of glutathione receptors on astrocytes and the activation of a second messenger system by glutathION suggest that glutathion may be a neuropeptide in the central nervous system.About:
This article is published in Neuroscience.The article was published on 1992-12-01. It has received 68 citations till now. The article focuses on the topics: Glutathione binding & GPX5.read more
Citations
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Journal ArticleDOI
Metabolism and functions of glutathione in brain.
TL;DR: Recent results confirm the prominent role of astrocytes in glutathione metabolism and the defense against reactive oxygen species in brain and suggest an involvement of a compromised astroglial glutATHione system in the oxidative stress reported for neurological disorders.
Journal ArticleDOI
Glutathione dysregulation and the etiology and progression of human diseases.
Nazzareno Ballatori,Suzanne M. Krance,Sylvia Notenboom,Shujie Shi,Kim Tieu,Christine L. Hammond +5 more
TL;DR: The present report highlights and integrates the growing connections between imbalances in GSH homeostasis and a multitude of human diseases and suggests the high GSH content makes cancer cells chemoresistant, which is a major factor that limits drug treatment.
Journal ArticleDOI
Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death.
TL;DR: A GSH-depletion model of neurodegenerative disorders is provided, experimental verifications of this model are suggested, and potential therapeutic approaches for preventing or halting these diseases are proposed.
Journal ArticleDOI
Glutathione pathways in the brain
Ralf Dringen,Johannes Hirrlinger +1 more
TL;DR: Results on the export of GSH and GSSG from brain cells as well as on the functions of extracellular GSH in the brain are reviewed and implications of disturbed GSH pathways in brain for neurodegenerative diseases will be discussed.
Journal ArticleDOI
Differential compartmentalization of brain ascorbate and glutathione between neurons and glia
Margaret E. Rice,I Russo-Menna +1 more
TL;DR: The data suggest that ascorbate predominates in neurons, whereas glutathione is slightly predominant in glia, as well as neuron and glia involvement in disease states linked to oxidative stress.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
TL;DR: The use of avidin-biotin interaction in immunoenzymatic techniques provides a simple and sensitive method to localize antigens in formalin-fixed tissues.
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G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
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Hydroperoxide metabolism in mammalian organs.
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Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.
K. D. McCarthy,J. de Vellis +1 more
TL;DR: These preparations should significantly aid in efforts to examine the biochemistry, physiology, and pharmacology of these two major classes of central nervous system cells.