Journal ArticleDOI
Glycyrrhizic acid, active component from Glycyrrhizae radix, prevents toxicity of graphene oxide by influencing functions of microRNAs in nematode Caenorhabditis elegans
TLDR
The authors showed that the use of glycyrrhizae radix (GR) prevented toxicity of graphene oxide in Caenorhabditis elegans, and may provide novel strategies in the reducing potential side effects of nanoparticles.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2016-04-01. It has received 36 citations till now.read more
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Journal ArticleDOI
Polystyrene (nano)microplastics cause size-dependent neurotoxicity, oxidative damage and other adverse effects in Caenorhabditis elegans
TL;DR: Investigation of the effects of polystyrene N/MPs with diameter sizes of 100 and 500 nm at the nanoscale and 1.0 μm at the microscale suggests that (nano)microplastics can exert size-dependent toxicity and have extensive impacts on organisms.
Journal ArticleDOI
Transgenerational toxicity of nanopolystyrene particles in the range of μg L−1 in the nematode Caenorhabditis elegans
TL;DR: Enhancement of intestinal permeability and extension of defecation cycle length provide the explanation for the observed accumulation and translocation of nanopolystyrene particles in reproductive organs and demonstrate the potential transgenerational toxicity in the range of μg L−1 in environmental organisms.
Book
Nanotoxicology in Caenorhabditis elegans
TL;DR: The model animal of nematode Caenorhabditis elegans has become an important in vivo alternative assay system for toxicological study of different environmental toxicants or stresses and the several important values are introduced.
Journal ArticleDOI
An epigenetic signal encoded protection mechanism is activated by graphene oxide to inhibit its induced reproductive toxicity in Caenorhabditis elegans.
Yunli Zhao,Qiuli Wu,Dayong Wang +2 more
TL;DR: The identified epigenetic signal encoded protection mechanism activated by GO suggests a novel self-protection mechanism for organisms against the ENMs toxicity.
Journal ArticleDOI
Antimicrobial proteins in the response to graphene oxide in Caenorhabditis elegans
TL;DR: The results demonstrate the crucial protection role of antimicrobial proteins for animals in response to environmental ENMs’ exposure and elucidated different signaling cascades mediated by antimacterial proteins provide important molecular targets for future toxicity assessment and chemical modification of GO.
References
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Journal ArticleDOI
The genetics of caenorhabditis elegans
TL;DR: In this paper, the authors describe methods for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm.
Journal Article
The genetics of Caenorhabditis elegans.
TL;DR: Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
Journal ArticleDOI
Nano-graphene in biomedicine: theranostic applications
TL;DR: Graphene-based photothermal therapy has been realized, achieving excellent anti-tumor therapeutic efficacy in animal experiments and future prospects and challenges of using graphene-based materials for theranostic applications are discussed.
Journal ArticleDOI
Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.
Maxwell C.K. Leung,Phillip L. Williams,Alexandre Benedetto,Catherine Au,Kirsten J. Helmcke,Michael Aschner,Joel N. Meyer +6 more
TL;DR: It is argued for an increased role for C. elegans in complementing other model systems in toxicological research, including genome-wide screening for molecular targets of toxicity and rapid toxicity assessment for new chemicals.
Journal ArticleDOI
Graphene in biomedicine: opportunities and challenges
Liangzhu Feng,Zhuang Liu +1 more
TL;DR: The latest progress of using graphene for various biomedical applications, including drug delivery, cancer therapies and biosensing, is summarized and the opportunities and challenges in this emerging field are discussed.