Journal ArticleDOI
Granulocytotoxic antibodies in a patient with propylthiouracil-induced agranulocytosis.
M M Guffy,N E Goeken,C P Burns +2 more
TLDR
Agranulocytosis developed in a patient who was receiving propylthiouracil and Cytotoxicity was shown to be mediated by a complement-dependent IgM antibody.Abstract:
Agranulocytosis developed in a patient who was receiving propylthiouracil. Using a microgranulocytotoxicity assay, serum taken from the patient was shown to be strongly granulocytotoxic when tested against the patients granulocytes and those obtained from two of eight normal subjects. Tests for granulocyte agglutinins and for lymphocytotoxicity were negative. Granulocytotoxic activity decreased as the patient's peripheral granulocyte count recovered. Cytotoxicity was shown to be mediated by a complement-dependent IgM antibody.read more
Citations
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Journal ArticleDOI
The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions
TL;DR: It is reasonable to speculate that reactive metabolites generated by activated leukocytes, or neutrophil precursors in the bone marrow, could be responsible for drug-induced agranulocytosis and aplastic anemia.
Journal ArticleDOI
Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.
Journal ArticleDOI
Analysis of 754 cases of antithyroid drug-induced agranulocytosis over 30 years in Japan.
TL;DR: Agranulocytosis tends to occur abruptly within 3 months after initiation of ATD therapy, although it develops gradually in some patients, and providing every patient with sufficient information on agranulocyTosis is critical.
Journal ArticleDOI
Agranulocytosis induced by propylthiouracil: evidence of a drug dependent antibody reacting with granulocytes, monocytes and haematopoietic progenitor cells.
Willem E. Fibbe,Frans H.J. Claas,Wies Van der Star-Dijkstra,M. Ronald Schaafsma,Ronald H. B. Meyboom,J.H. Frederik Falkenburg +5 more
TL;DR: Results indicate that the agranulocytosis was mediated by a PTU dependent antibody that affected both mature blood cells and bone precursor cells.
Journal ArticleDOI
Drug metabolism by leukocytes and its role in drug-induced lupus and other idiosyncratic drug reactions.
TL;DR: A unifying hypothesis is that an infection, or other inflammatory condition, may be an important risk factor for a hypersensitivity reaction because such a stimulus leads to activation of leukocytes which can lead to formation of reactive metabolites from certain drugs.
References
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Journal ArticleDOI
Agranulocytosis Associated with Antithyroid Drugs: Effects of Patient Age and Drug Dose
D S Cooper,David Goldminz,Ann A. Levin,Paul W. Ladenson,Gilbert H. Daniels,Mark E. Molitch,E C Ridgway +6 more
TL;DR: The data suggest that antithyroid drugs should be administered cautiously to patients over age 40, and low-dose methimazole therapy may be safer than high-dose therapy or treatment with conventional doses of propylthiouracil.
Journal ArticleDOI
Drug-induced immunological neutropenia
TL;DR: Antineutrophil antibody capable of opsonising normal neutrophils was detected in the sera of 16 neutropenic patients receiving various drugs, and complement-dependent opsonic activity was demonstrated in 2 patients and in another patient receiving multiple drugs, a complement-independent IgG antibody was demonstrated.
Journal ArticleDOI
An isologous antigen-antibody reaction with human neutrophiles, related to neonatal neutropenia.
TL;DR: An antibody was obtained from a multiparous female, none of whose children ever presented any evidence of neutropenia, which had previously been shown to detect an antigen common to leukocytes, platelets, and several solid tissues.
Journal ArticleDOI
Studies on levamisole-induced agranulocytosis
John S. Thompson,J. M. Herbick,Lynell Warren Klassen,Charles D. Severson,V. L. Overlin,J. W. Blaschke,M. A. Silverman,C. L. Vogel +7 more
TL;DR: Whereas leukoagglutination was negative, fluorochromatic microgranulocytotoxicity (GCY) tests were positive with serum from 10 of 10 acutely neutropenic patients, suggesting the possibility of identifying those at risk well before the onset of neutropenia.
Journal Article
Agranulocytosis and antithyroid drugs.
TL;DR: It is important to be aware of the clinical features of granulocytopenic reactions due to antithyroid drugs and to be mindful of the risks and benefits of these drugs.