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Open AccessJournal ArticleDOI

Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases.

Wanda C. Reygaert
- 17 Jul 2018 - 
- Vol. 2018, pp 9105261-9105261
TLDR
Consumption of green tea has been shown to distribute these compounds and/or their metabolites throughout the body, which allows for not only the possibility of treatment of infections but also the prevention of infections.
Abstract
Green tea is one of the most popular drinks consumed worldwide. Produced mainly in Asian countries from the leaves of the Camellia sinensis plant, the potential health benefits have been widely studied. Recently, researchers have studied the ability of green tea to eradicate infectious agents and the ability to actually prevent infections. The important components in green tea that show antimicrobial properties are the catechins. The four main catechins that occur in green tea are (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG). Of these catechins, EGCG and EGC are found in the highest amounts in green tea and have been the subject of most of the studies. These catechins have been shown to demonstrate a variety of antimicrobial properties, both to organisms affected and in mechanisms used. Consumption of green tea has been shown to distribute these compounds and/or their metabolites throughout the body, which allows for not only the possibility of treatment of infections but also the prevention of infections.

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Beneficial Properties of Green Tea Catechins.

TL;DR: It needs to be clearly emphasized that green tea as well as green tea catechols cannot replace the standard chemotherapy, Nonetheless, their beneficial effects may support the standard anticancer approach.
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Role of Phytochemicals in Cancer Prevention.

TL;DR: The mechanism of chemopreventive and anticancer effects of several natural agents have been addressed, indicating that dietary components such as capsaicin, cucurbitacin B, isoflavones, catechins, lycopenes, benzyl isothiocyanate, phenethyl isothionine, and piperlongumine have demonstrated inhibitory effects on cancer cells indicating that they may serve as chemop reventive agents.
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Health Benefits and Chemical Composition of Matcha Green Tea: A Review

TL;DR: In this article, a review of the health benefits of matcha tea is presented, and the main bioactive compounds in a systematic manner, including theanine, caffeine, chlorophyll and various types of catechins.
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Food as medicine: A possible preventive measure against coronavirus disease (COVID-19).

TL;DR: The present review was designed to report important functional food plants with immunomodulatory and anti‐viral properties that might reduce the risk of COVID‐19 and initiate a rapid recovery in cases of SARS‐CoV‐2 infection.
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Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG.

TL;DR: Molecular and ecophysiological aspects in this review illustrates why plants control the formation of biofilms on their surfaces by producing anti-amyloidogenic compounds such as EGCG, and suggests that searching for ‘magic bullet’ anti-biofilm agents is an unrealistic goal.
References
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Journal Article

Pharmacokinetics of Tea Catechins after Ingestion of Green Tea and (−)-Epigallocatechin-3-gallate by Humans: Formation of Different Metabolites and Individual Variability

TL;DR: In this paper, the pharmacokinetic parameters of green tea polyphenols were analyzed after administration of a single oral dose of a decaffeinated green tea (20 mg tea solids/kg) or EGCG (2 mg/kg).
Journal Article

Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals.

TL;DR: It is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 8-16 cups of green tea once a day or in divided doses twice a day for 4 weeks, and the pharmacokinetics of the conjugated metabolites of epigallocatechin and epicatechin were not affected by repeated green teapolyphenol treatment.
Journal Article

Pharmacokinetics of Tea Catechins after Ingestion of Green Tea and (−)-Epigallocatechin-3-gallate by Humans

TL;DR: The pharmacokinetic parameters of EGCG, EGC, and EC were analyzed after administration of a single oral dose of green tea or decaffeinated green tea to eight subjects and may be useful for designing the dose and dose frequency in intervention studies with tea and for development of biomarkers of tea consumption.
Journal Article

Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers.

TL;DR: The bioavailability of green tea catechins in humans has been investigated in this article, where the authors measured the time-dependent plasma concentrations and urinary excretion of tea catechin and found that EGC and EC were excreted in the urine within 8 hours after drinking green tea.
Journal Article

Analysis of plasma and urinary tea polyphenols in human subjects.

TL;DR: Methods for the analysis of tea polyphenols in human plasma and urine samples using HPLC with the coulochem electrode array detection system to develop biomarkers for tea consumption established good quantitative relationships for a large concentration range of teapolyphenols.
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