The Role of Catechins in Cellular Responses to Oxidative Stress
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TLDR
The biochemical properties of catechins, their antioxidant activity, and the mechanisms of action involved in the prevention of oxidative stress-caused diseases are reviewed.Abstract:
Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes. Oxidative stress and ROS are implicated in aging and related dysfunctions, such as neurodegenerative disease, cancer, cardiovascular diseases, and diabetes. Due to their antioxidant properties, catechins may be beneficial in preventing and protecting against diseases caused by oxidative stress. This article reviews the biochemical properties of catechins, their antioxidant activity, and the mechanisms of action involved in the prevention of oxidative stress-caused diseases.read more
Citations
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Polyphenols: A concise overview on the chemistry, occurrence, and human health
Alessandra Durazzo,Massimo Lucarini,Eliana B. Souto,Eliana B. Souto,Carla Cicala,Elisabetta Caiazzo,Angelo A. Izzo,Ettore Novellino,Antonello Santini +8 more
TL;DR: This review gives an updated picture of each class of phenolic compounds and their properties and the use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.
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Antioxidant mechanism of tea polyphenols and its impact on health benefits.
TL;DR: The application of tea polyphenols in human and animal health is examined, providing a scientific basis for this application in addition to proposing future directions for the development of this resource.
Journal ArticleDOI
Beneficial Properties of Green Tea Catechins.
Claudia Musial,Alicja Kuban-Jankowska,Magdalena Gorska-Ponikowska,Magdalena Gorska-Ponikowska +3 more
TL;DR: It needs to be clearly emphasized that green tea as well as green tea catechols cannot replace the standard chemotherapy, Nonetheless, their beneficial effects may support the standard anticancer approach.
Journal ArticleDOI
Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease.
Alexa Serino,Gloria Salazar +1 more
TL;DR: Molecular mechanisms by which polyphenols improve anti-oxidant capacity, mitochondrial function and autophagy, while reducing oxidative stress, inflammation and cellular senescence in vascular smooth muscle cells and endothelial cells are discussed.
Journal ArticleDOI
Catechin in Human Health and Disease
TL;DR: Catechin, the name of which is derived from catechU of the extract of Acacia catechu L, is a plant isolate from the fruit of the Acacia genus Acacia.
References
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Free radicals and antioxidants in normal physiological functions and human disease
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Journal ArticleDOI
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