Journal ArticleDOI
Growth factors in development, transformation, and tumorigenesis
Michael Cross,T. Michael Dexter +1 more
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Mammalian tissue development and regeneration take place within a milieu of regulatory growth factors, such that survival, proliferation, differentiation, and certain aspects of cell behavior are all influenced by a balance between stimulatory and inhibitory signals.About:
This article is published in Cell.The article was published on 1991-01-25. It has received 677 citations till now. The article focuses on the topics: Growth factor & Cellular differentiation.read more
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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
Journal ArticleDOI
Oncogenes and signal transduction
Lewis C. Cantley,Kurt R. Auger,Christopher L. Carpenter,Brian C. Duckworth,Andrea Graziani,Rosana Kapeller,Stephen P. Soltoff +6 more
TL;DR: The protein-tyrosine kinase oncogenes will be the primary focus of the review as discussed by the authors, however, biochemical connections between the protein tyrosine Kinases and oncoproteins of the Ras,Raf,Fos,Jun, and Rel families as well as the protein kinase C family are also discussed.
Journal ArticleDOI
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
TL;DR: A review of growth factor delivery in tissue engineering provides an overview of fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives.
Journal ArticleDOI
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
TL;DR: The results demonstrate that the FGF signaling pathway plays an important role in early embryogenesis, particularly in the formation of the posterior and lateral mesoderm.
Journal ArticleDOI
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts.
TL;DR: It is shown that microinjection of the related human Cdc42Hs into Swiss 3T3 fibroblasts induced the formation of peripheral actin microspikes, determined by staining with phalloidin, and that Cdc 42Hs plays an important role in determining mammalian cell morphology.
References
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Journal ArticleDOI
Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
Journal ArticleDOI
Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.
TL;DR: General themes are emerging that yield new strategies for prognosis and therapy of hu- man metastatic cancer, and an imbalanced regulation of motility and proteoly- sis appears to be required for invasion and metastasis.
Journal ArticleDOI
Stimulation of 3T3 cells induces transcription of the c- fos proto-oncogene
TL;DR: Transcription of the c-fos proto-oncogene is greatly increased within minutes of administering purified growth factors to quiescent 3T3 cells, and this stimulation is the most rapid transcriptional response to peptide growth factors yet described, implying a role for c- fos in cell-cycle control.
Journal ArticleDOI
Oncogenes and signal transduction
Lewis C. Cantley,Kurt R. Auger,Christopher L. Carpenter,Brian C. Duckworth,Andrea Graziani,Rosana Kapeller,Stephen P. Soltoff +6 more
TL;DR: The protein-tyrosine kinase oncogenes will be the primary focus of the review as discussed by the authors, however, biochemical connections between the protein tyrosine Kinases and oncoproteins of the Ras,Raf,Fos,Jun, and Rel families as well as the protein kinase C family are also discussed.
Journal ArticleDOI
Close similarity of epidermal growth factor receptor and v- erb-B oncogene protein sequences
Julian Downward,Yosef Yarden,E. Mayes,G. Scrace,Nick Totty,P. Stockwell,Axel Ullrich,Joseph Schlessinger,Mike Waterfield +8 more
TL;DR: Six peptides derived from the human epidermal growth factor receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis virus (AEV).
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Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more