Gut Microbiota Composition Is Related to AD Pathology
Barbara J. H. Verhaar,Heleen M.A. Hendriksen,Francisca A. de Leeuw,Astrid S. Doorduijn,Mardou van Leeuwenstijn,Charlotte E. Teunissen,Frederik Barkhof,Philip Scheltens,Robert Kraaij,Cornelia M. van Duijn,Max Nieuwdorp,Majon Muller,Wiesje M. van der Flier +12 more
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TLDR
Gut microbiota composition was associated with amyloid and p-tau status and it was extended on recent studies that observed associations between SCFA levels and AD CSF biomarkers by showing that lower abundances of SCFA-producing microbes were associated with higher odds of positive amyloids and tau status.Citations
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Roseburia hominis Alleviates Neuroinflammation via Short‐Chain Fatty Acids through Histone Deacetylase Inhibition
TL;DR: Findings suggest that R. hominis provides a potential psychoprobiotic to reduce neuroinflammation by producing propionate and butyrate, which served as HDAC inhibitors.
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Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study
Zheng Zhu,Xiaoxi Ma,Jie Wu,Zhenxu Xiao,Wanqing Wu,Saineng Ding,Li Zheng,Xiaoniu Liang,Jianfeng Luo,Ding Ding,Qianhua Zhao +10 more
TL;DR: The hypothesis that intestinal microorganisms change in MCI and AD is supported, and the alteration in specific taxa correlated closely with clinical manifestations, indicating the potential role in AD pathogenesis.
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The Many Ages of Microbiome–Gut–Brain Axis
Daniela Ratto,Elisa Roda,Marcello Romeo,Maria Teresa Venuti,Anthea Desiderio,Giuseppe Lupo,Enrica Capelli,Anna Sandionigi,Paola Rossi +8 more
TL;DR:
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The Interdependence Between Diet, Microbiome, And Human Body Health - A Systemic Review
TL;DR: In this article , the main roles of the intestinal microbiome, its composition, and implications in maintaining the health of the organism are discussed, and it has been shown so far that the intestinal microbial community is itself an organ that has its metabolic activity influencing the entire metabolism of the body host.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Proceedings ArticleDOI
XGBoost: A Scalable Tree Boosting System
Tianqi Chen,Carlos Guestrin +1 more
TL;DR: XGBoost as discussed by the authors proposes a sparsity-aware algorithm for sparse data and weighted quantile sketch for approximate tree learning to achieve state-of-the-art results on many machine learning challenges.
Journal ArticleDOI
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
TL;DR: The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.
Proceedings ArticleDOI
XGBoost: A Scalable Tree Boosting System
Tianqi Chen,Carlos Guestrin +1 more
TL;DR: This paper proposes a novel sparsity-aware algorithm for sparse data and weighted quantile sketch for approximate tree learning and provides insights on cache access patterns, data compression and sharding to build a scalable tree boosting system called XGBoost.
Journal ArticleDOI
Diversity and Evenness: A Unifying Notation and Its Consequences
TL;DR: Three commonly used measures of diversity, Simpson's index, Shannon's entropy, and the total number of species, are related to Renyi's definition of a generalized entropy, according to which there is a continuum of possible diversity measures.
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