Hemorheological Disorders in Diabetes Mellitus
TLDR
The present paper explains how the increased blood viscosity adversely affects the microcirculation in diabetes, leading to microangiopathy.Abstract:
The objective of the present study is to review hemorheological disorders in diabetes mellitus. Several key hemorheological parameters, such as whole blood viscosity, erythrocyte deformability, and aggregation, are examined in the context of elevated blood glucose level in diabetes. The erythrocyte deformability is reduced, whereas its aggregation increases, both of which make whole blood more viscous compared to healthy individuals. The present paper explains how the increased blood viscosity adversely affects the microcirculation in diabetes, leading to microangiopathy.read more
Citations
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Biomechanical properties of red blood cells in health and disease towards microfluidics.
TL;DR: The aim of this review is to summarize currently available reports on RBC deformability and to highlight its association with various human diseases such as hereditary disorders, metabolic disorders, adenosine triphosphate-induced membrane changes, oxidative stress, and paroxysmal nocturnal hemoglobinuria.
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Lipid Composition of Cell Membranes and Its Relevance in Type 2 Diabetes Mellitus
TL;DR: Key outcomes of the reviewed studies appear to support the hypotheses that the flexibility of a membrane determined by the ratio of (poly)unsaturated to saturated fatty acyl chains of its phospholipids influences the effectiveness of glucose transport by insulin-independent glucose transporters and the insulin-dependent GLUT4.
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Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial
Mariona Balfegó,Silvia Canivell,Felicia A. Hanzu,Aleix Sala-Vila,Margarita Martinez-Medina,Serafín Murillo,Teresa Mur,Elena G. Ruano,Francisca Linares,Nuria Porras,Silvia Valladares,María I. Fontalba,Elena Roura,Anna Novials,Cristina Hernández,Gloria Aranda,Antoni Sisó-Almirall,Gemma Rojo-Martínez,Rafael Simó,Ramon Gomis +19 more
TL;DR: Although enriching diet with 100 g of sardines 5 days a week during 6 months to a type 2 diabetes standard diet seems to have neutral effects on glycemic control in drug-naïve patients with type 1 diabetes, this nutritional intervention could have beneficial effects on cardiovascular risk.
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Innovations in gene and growth factor delivery systems for diabetic wound healing.
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Human red blood cell behavior under homogeneous extensional flow in a hyperbolic-shaped microchannel
TL;DR: These in vitro experiments show the potential of using microfluidic systems with hyperbolic-shaped microchannels both for the separation of the RBCs from plasma and to assess changes in RBC deformability in physiological and pathological situations for clinical purposes.
References
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Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell collaborative heart disease studies
John W. G. Yarnell,Ian A. Baker,Peter M. Sweetnam,D. Bainton,John R. O'Brien,Philip J. Whitehead,Peter Creighton Elwood +6 more
TL;DR: The results suggest that at least part of the effect of smoking on IHD is mediated through fibrinogen, viscosity, and white blood cell count, and these three variables significantly improve the fit of a logistic regression model containing all the main conventional risk factors.