Journal ArticleDOI
Heterogeneous Catalytic Hydrogenation Reactions in Continuous‐Flow Reactors
TLDR
In this review article recent developments in continuous flow heterogeneous catalytic hydrogenation reactions using molecular hydrogen are summarized.Abstract:
Microreactor technology and continuous flow processing in general are key features in making organic synthesis both more economical and environmentally friendly. Heterogeneous catalytic hydrogenation reactions under continuous flow conditions offer significant benefits compared to batch processes which are related to the unique gas-liquid-solid triphasic reaction conditions present in these transformations. In this review article recent developments in continuous flow heterogeneous catalytic hydrogenation reactions using molecular hydrogen are summarized. Available flow hydrogenation techniques, reactors, commonly used catalysts and examples of synthetic applications with an emphasis on laboratory-scale flow hydrogenation reactions are presented.read more
Citations
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Journal ArticleDOI
The Hitchhiker's Guide to Flow Chemistry
TL;DR: This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts.
Journal ArticleDOI
Continuous‐Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
TL;DR: This Review discusses recent literature examples of continuous-flow organic synthesis where hazardous reactions or extreme process windows have been employed, with a focus on applications of relevance to the preparation of pharmaceuticals.
Journal ArticleDOI
Continuous flow reactors: a perspective
Charlotte Wiles,Paul Watts +1 more
TL;DR: In this paper, the development made into the application of continuous flow reactors for sustainable chemical research and production is discussed, with aspects of continuous processing featuring heavily in efforts towards increasing the green prospects of pharmaceutical and fine chemical manufacturing.
Journal ArticleDOI
The role of flow in green chemistry and engineering
TL;DR: In this paper, the authors use selected examples to demonstrate how continuous methods of synthesis can be greener than batch synthesis on a small and a large scale, and demonstrate how such methods can help bridge the large gap between academic and industrial settings by often providing a more reproducible, scalable, safe and efficient option for performing chemical reactions.
The role of flow in green chemistry and engineering
TL;DR: In this review, selected examples are used to demonstrate how continuous methods of synthesis can be greener than batch synthesis on a small and a large scale.
References
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Reference BookDOI
Handbook of Heterogeneous Catalysis
TL;DR: This paper presents a meta-modelling system that automates the very labor-intensive and therefore time-heavy and therefore expensive and expensive process of characterization and activation of Solid Catalysts.
Journal ArticleDOI
Origins, Current Status, and Future Challenges of Green Chemistry†
TL;DR: The origins and basis of green chemistry chart a course for achieving environmental and economic prosperity inherent in a sustainable world.
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The E Factor: fifteen years on
TL;DR: In this article, the effect of the E Factor concept has had over the last fifteen years on developments in the chemical industry and pharmaceutical industry with regard to waste minimisation and to assess its current status in the broader context of green chemistry and sustainability.
Journal ArticleDOI
On Inventing Reactions for Atom Economy
TL;DR: Using mechanistic reasoning, over 20 new processes of varying complexity have been designed and implemented that involved C-C bond-forming reactions and the prospect for such developments is probed in the context of ruthenium-catalyzed reactions.
Journal ArticleDOI
Supercritical and near-critical CO2 in green chemical synthesis and processing
TL;DR: A review of the use of CO 2 to create greener processes and products, with a focus on research and commercialization efforts performed since 1995, is presented in this article, which reveals that careful application of CO2 technology can result in products (and processes) that are cleaner, less expensive and of higher quality.