Journal ArticleDOI
Highland mate: Edible and functional foods in traditional medicine for the prevention and treatment of hypoxia-related symptoms
TLDR
Wang et al. as discussed by the authors provided a more comprehensive analysis of these nutraceuticals, which can be used to prevent and treat symptoms of altitude hypoxia in the Chinese market.About:
This article is published in Current Opinion in Pharmacology.The article was published on 2021-09-08. It has received 9 citations till now. The article focuses on the topics: Altitude sickness & Altitude Hypoxia.read more
Citations
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Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer
Yingchun Zhu,Na Xie,Y.W. Chai,Yisen Nie,Ke-Min Liu,Yufei Liu,Yang Yang,Jinsong Su,Chuantao Zhang +8 more
TL;DR: A timely and comprehensive summary of the detailed molecular mechanisms of BBR in treating three types of cancer by inducing apoptosis is provided and the existing challenges and strategies to improve BBR’s bioavailability are discussed.
Journal ArticleDOI
Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling.
TL;DR: Wang et al. as discussed by the authors explored the mitochondrial protection of Sal and the involved mechanisms related to mitochondrial dynamics homeostasis on hypoxia-induced injury of HT22 cells, showing that Sal significantly increased the cell viability and increased the protein levels of Sirt1, p53, ac-p53, Na+-K+-ATPase activity.
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Dehydrocostuslactone attenuated oxygen and glucose deprivation/reperfusion-induced PC12 cell injury through inhibition of apoptosis and autophagy by activating the PI3K/AKT/mTOR pathway.
TL;DR: In this article, the authors investigated the effect of dehydrocostuslactone (DHL) on PC12-cells injury induced by oxygen and glucose deprivation/reperfusion (OGD/R) and its possible mechanism on the PI3K/AKT/mTOR pathway.
Journal ArticleDOI
Ellagic Acid: A Dietary-Derived Phenolic Compound for Drug Discovery in Mild Cognitive Impairment
TL;DR: An overview of the physicochemical properties, source, and pharmacokinetics of EA is provided and the importance and mechanisms of EA in the prevention and management of MCI are emphasized to reinforce the scientific facticity of the beneficial effects of EA against MCI.
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Anti-inflammatory and anti-apoptotic effects of Shaoyao decoction on X-ray radiation-induced enteritis of C57BL/6 mice.
Zhuohong Li,Ying Gao,Lei Du,Ye Yuan,Wenbo Huang,Xi Fu,Yongliang Huang,Xufan Zhang,Fengming You,Shijie Li +9 more
TL;DR: Wang et al. as discussed by the authors investigated the effect of Shaoyao decoction on X-ray radiation-induced enteritis of C57BL/6 mice and found that SYD can significantly ameliorate the apoptosis of colon cells, evidenced by reduced positive expression of TUNEL staining.
References
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Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Wenjing Yang,Tianming Yu,Xiangsheng Huang,Anthony J. Bilotta,Leiqi Xu,Yao Lu,Jiaren Sun,Fan Pan,Jia Zhou,Wenbo Zhang,Suxia Yao,Craig L. Maynard,Nagendra Singh,Sara M. Dann,Zhanju Liu,Yingzi Cong +15 more
TL;DR: It is shown that microbiota-derived short-chain fatty acids (SCFAs) promote IL-22 production by CD4+ T cells and ILCs through G-protein receptor 41 (GPR41) and inhibiting histone deacetylase (HDAC) and that SCFA supplementation enhances IL- 22 production, which protects intestines from inflammation.
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Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion.
Nicole E. Scharping,Dayana Rivadeneira,Ashley V. Menk,Paolo Vignali,B. Rhodes Ford,Natalie Rittenhouse,Ronal Peralta,Yiyang Wang,Yupeng Wang,Kristin DePeaux,Amanda C. Poholek,Greg M. Delgoffe +11 more
TL;DR: In this paper, the authors hypothesized that metabolic stress alters T cell responses to other signals, specifically, persistent antigenic stimulation, and the combination rapidly drove T cell dysfunction consistent with exhaustion.
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Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms.
TL;DR: Wang et al. as mentioned in this paper discussed principles of TCM in curing infectious disease, and clinical evidence and mechanisms of the 6 most effective TCM recipes used in treating COVID-19 in 92% of all of the confirmed cases in China.
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Bioactivities, biosynthesis and biotechnological production of phenolic acids in Salvia miltiorrhiza.
TL;DR: Recent advances in bioactivities, biosynthetic pathway and biotechnological production of phenolic acid ingredients were summarized and future prospective was also discussed.
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Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
Rashi Singhal,Yatrik M. Shah +1 more
TL;DR: This review aims to outline the major roles of physiological and pathological hypoxic conditions in the maintenance of intestinal homeostasis and in the onset and progression of disease with a major focus on understanding the complex pathophysiology of the intestine.