Journal ArticleDOI
Highly diastereoselective cycloaddition reactions of variously substituted 1-thia- and 1-thia-3-aza-buta-1,3-dienes. Synthesis of enantiomerically pure 5,6-dihydro-4H-[1,3]thiazines and 3,4-dihydro-2H-thiopyrans
TLDR
The cycloaddition of 2- or 2,3-substituted 1-thia- and 1 -thia-3-aza-4-dimethylamino-buta-1, 3-dienes with various dienophiles in the presence of a Lewis acid provides a rapid and diastereoselective access to the 3,4-dihydro-2H-thiopyran and 5,6-diphysine backbones as discussed by the authors.About:
This article is published in Tetrahedron.The article was published on 2004-02-16. It has received 21 citations till now. The article focuses on the topics: Cycloaddition & Thiazine.read more
Citations
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Journal ArticleDOI
Synthesis of Carbocyclic and Heterocyclic β-Aminocarboxylic Acids
TL;DR: These compounds are found in natural products and antibiotics, and are also considered important precursors for pharmacologically interesting β-lactams and other bioactive compounds.
Journal ArticleDOI
Asymmetric Construction of Spiro[thiopyranoindole-benzoisothiazole] Scaffold via a Formal [3 + 3] Spiroannulation
TL;DR: An enantioselective formal thio[3 + 3] spiroannulation reaction of indoline-2-thiones to 1-azadienes has been developed by the use of a quinine-derived bifunctional tertiary amine-thiourea catalyst.
Journal ArticleDOI
Asymmetric synthesis of chiral dihydrothiopyrans via an organocatalytic enantioselective formal thio [3 + 3] cycloaddition reaction with binucleophilic bisketone thioethers.
Shengzheng Wang,Yongqiang Zhang,Guoqiang Dong,Shanchao Wu,Shiping Zhu,Zhenyuan Miao,Jianzhong Yao,Hao Li,Jian Li,Wannian Zhang,Chunquan Sheng,Wei Wang +11 more
TL;DR: An unprecedented organocatalytic highly enantioselective approach to a 3,4-dihydro-2H-thiopyran scaffold with two contiguous stereogenic centers has been implemented through a formal thio [3 + 3] cycloaddition process involving a Michael-aldol condensation cascade sequence.
Journal ArticleDOI
Nitrile Ylides: Diastereoselective Cycloadditions using Chiral Oxzolidinones Without Lewis Acid
TL;DR: This work shows that nitrile ylide cycloadditions to electron-poor acceptors attached to chiral auxiliaries proceed in high yield and stereoselectivity in the absence of Lewis acids.
Journal ArticleDOI
Unusual conversion of substituted-3-formylchromones to 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones: a facile and efficient route to novel 1,2,4-dithiazoles
Tilak Raj,Mohan Paul S. Ishar,Vivek K. Gupta,Ajay Pal Singh Pannu,Priyanka Kanwal,Gurpinder Singh +5 more
TL;DR: Substituted 3-formylchromones react with 2-phenyl-4-dimethylamino-1-thia-3-azabuta-1,3-diene ( 4 ) or thio-benzamide ( 7 ) by heating their toluene solution in a sealed tube to give novel substituted 3-(5phenyl)-3 H -[1,2,4]dithiazol-3yl)chromen-4ones ( 6a − e ) in high yields as discussed by the authors.
References
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ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI)
TL;DR: L Lists of software presented and~or reviewed in the Journal of Applied Crystallography are available on the World Wide Web at the above address, together with information about the availability of the software where this is known.
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SIR97: a new tool for crystal structure determination and refinement
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TL;DR: SIR97 is the integration of two programs, SIR92 and CAOS, the first devoted to the solution of crystal structures by direct methods, the second to refinement via least-squares–Fourier procedures.
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The Diels--Alder reaction in total synthesis.
TL;DR: The Diels-Alder reaction has both enabled and shaped the art and science of total synthesis over the last few decades to an extent which has yet to be eclipsed by any other transformation in the current synthetic repertoire as mentioned in this paper.
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Catalytic enantioselective Diels--Alder reactions: methods, mechanistic fundamentals, pathways, and applications.
TL;DR: Research by this group on the development and understanding of enantioselective versions of the Diels-Alder reactions is described, based on presentations given first at the University of Cologne, Germany, then at the Roger Adams Award Symposium, and later at the Bürgenstock Conference of 2001.