Journal ArticleDOI
Highly efficient, reusable functionalized pyridinium salts as a catalyst for the simple and cost-effective preparation of tetrahydro[b]benzopyran derivatives
TLDR
In this article , a series of pyridinium-based ionic liquids (PBILs) were synthesized through a simple method, which was initially evaluated as catalysts for the synthesis of tetrahydro[b]benzopyran derivatives via a one-pot three-component reaction involving aldehydes, malononitrile, and dimedone.Abstract:
In this work, a series of pyridinium-based ionic liquids (PBILs) were synthesized.
Pyridinium-based ionic liquids (PBILs) were synthesized through a simple method, which was initially evaluated as catalysts for the synthesis of tetrahydro[b]benzopyran derivatives via a one-pot three-component reaction involving aldehydes, malononitrile, and dimedone.
The PBILs perform well in this condensation reaction, especially 1-methylpyridin-1-ium dimethyl phosphate (MPDMP).
The advantages of this procedure are good yields, short reaction time, simplicity of implementation, and inexpensive starting materials.
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Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives
TL;DR: In this article, the synthesis and biological activity of heterocyclic compounds synthesized by carbon suboxide was investigated and some 2-oxo (2H) 1-benzopyran-3-carboxamide derivatives were screened.
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Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities.
TL;DR: The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported and antimicrobial activity was shown for most of the synthesized compounds.
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Nitriles in heterocyclic synthesis: novel synsthesis of benzo[c]-coumarin and of benzo[c]pyrano[3,2-c]quinoline derivatives
TL;DR: Syntheses a partir de methyl-4 oxo-2 chromenecarbonitrile-3 ou de dihydro-5,6 dimethyl-4,6 dioxo- 2,5 pyranno [3,2-c] quinoleinecarbonitrile,3, et d'α-cyano ou α-ethoxycarbonyl cinnamonitriles
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Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides
Paul W. Smith,Steven L. Sollis,Peter D. Howes,Peter C. Cherry,Ian D. Starkey,Kevin N. Cobley,Helen Weston,Jan Scicinski,Merritt Andrew Thomas,Andrew R. Whittington,P. G. Wyatt,Neil Taylor,Darren V. S. Green,R. C. Bethell,Safia Madar,Robert J. Fenton,Peter J. Morley,Tony Pateman,Alan Beresford +18 more
TL;DR: 4-Amino- and 4-guanidino-4H-pyran-6-carboxamides 4 and 5 related to zanamivir (GG167) are a new class of inhibitors of influenza virus sialidases and several of the most potent analogues displayed useful antiviral activity in vivo when evaluated in a mouse model of influenza A virus infection.
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Friedländer reaction on 2-amino-3-cyano-4H-pyrans : Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analogues
A. Martinez‐Grau,J. L. Marco +1 more
TL;DR: The Friedlander reaction of densely functionalized 2-amino-3-cyano-4H-pyrans (1) with cyclohexanone has afforded in one step and good yield 5.