Journal ArticleDOI
Histologic Lichenoid Features in Oral Dysplasia and Squamous Cell Carcinoma
TLDR
This study confirms the frequent correlation of lichenoid characteristics in oral premalignant and malignant lesions in epithelial dysplasia and squamous cell carcinoma.Abstract:
Objective This study describes the occurrence of histopathologic characteristics of oral lichenoid mucositis in epithelial dysplasia and squamous cell carcinoma. Study Design This retrospective review examined 352 histologic specimens of group 1 (mild to moderate dysplasia), group 2 (severe dysplasia or carcinoma in situ), and group 3 (squamous cell carcinoma) for correlation between 5 histologic characteristics frequently found in oral lichen planus and grade, age, gender, and oral subsite. Results In this sample, 29% of all cases exhibited 3 or more lichenoid features. Lichenoid features were significantly more frequent in group 1 over group 2 lesions for cases meeting a minimum lichenoid threshold ( P = .001). No statistically significant patterns were noted for age or gender. The buccal mucosa was significantly overrepresented ( P = .039) and the floor of the mouth was significantly underrepresented ( P = .049) in regard to lichenoid feature frequency. Conclusions This study confirms the frequent correlation of lichenoid characteristics in oral premalignant and malignant lesions.read more
Citations
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Journal ArticleDOI
Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology
TL;DR: The diagnostic process of OLP requires continued clinical follow-up after initial biopsy, because OLP mimics can manifest, necessitating an additional biopsy for direct immunofluorescence study and/or histopathological evaluation in order to reach a final diagnosis.
Journal ArticleDOI
Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review
TL;DR: The clinical and histopathologic characteristics of a variety of ulcerated lesions found in the oral cavity are described to establish a diagnosis in cases that are not clinically identifiable or do not respond as expected to treatment.
Journal ArticleDOI
Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
TL;DR: The histopathologic assessment of OPMDs is an area of subjectivity, and oral epithelial dysplasia (OED) is fraught with both interrater variability and intrarater variability, but the concept of atypical verrucous lesions, particularly as it pertains to proliferative verruCous leukoplakia, suffers from lack of histopathological diagnostic criteria.
Journal ArticleDOI
Oral lichenoid lesions: distinguishing the benign from the deadly.
TL;DR: Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time, requiring careful correlation of the clinical and pathologic features.
Journal ArticleDOI
Oral epithelial dysplasia: Recognition, grading and clinical significance
TL;DR: In this article, the use of histological features of epithelial dysplasia is discussed, and the predictive values of three-grade and binary systems are summarised, including lichenoid and verrucous lesions, keratosis of unknown significance, differentiated and basaloid epithelia.
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Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications
TL;DR: In this article, the authors studied the correlation between clinical and histopathologic assessment of oral lichen planus (OLP) and proposed diagnostic refinements, if appropriate, based on the findings of the present study.
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Oral lichen planus: controversies surrounding malignant transformation.
TL;DR: A possible a molecular basis for the malignant transformation in this disease is proposed and the optimum management of patients is suggested to ensure the early diagnosis of transformation.
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Oral lichen planus: the evidence regarding potential malignant transformation.
TL;DR: A critical review of the literature was undertaken to determine if there is valid data to support the contention that oral lichen planus represents a disease with significant potential for malignant degeneration.