Histological confirmation and biological significance of cartilage canals demonstrated using high field MRI in swine at predilection sites of osteochondrosis
Ferenc Tóth,Mikko J. Nissi,Jinjin Zhang,Michael Benson,Sebastian Schmitter,Jutta M. Ellermann,Cathy S. Carlson +6 more
TLDR
The ability to visualize cartilage canal blood vessels by MRI, without using a contrast agent, will allow future longitudinal studies to evaluate their role in developmental orthopedic disease.About:
This article is published in Journal of Orthopaedic Research.The article was published on 2013-12-01 and is currently open access. It has received 26 citations till now. The article focuses on the topics: Osteochondritis dissecans & Osteochondrosis.read more
Citations
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An Update on the Pathogenesis of Osteochondrosis
TL;DR: In pigs and horses, research is currently aimed at discovering the cause of the vascular failure in osteochondrosis, and studies of spontaneous lesions suggest that failure is associated with the process of incorporating blood vessels into the advancing ossification front during growth.
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Novel Application of Magnetic Resonance Imaging Demonstrates Characteristic Differences in Vasculature at Predilection Sites of Osteochondritis Dissecans.
Ferenc Tóth,Mikko J. Nissi,Jutta M. Ellermann,Luning Wang,Kevin G. Shea,John D. Polousky,Cathy S. Carlson +6 more
TL;DR: Nearly identical vascular architecture at the shared primary predilection site of osteochondrosis/osteochondritis dissecans in the femoral condyles in human beings and pigs suggests that vascular failure, which is known to be central to the pathogenesis of this disease in pigs, may also play a role in humans.
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Improved Visualization of Cartilage Canals Using Quantitative Susceptibility Mapping.
TL;DR: Improved and artifact-free 3-D visualization of the cartilage canals was demonstrated by QSM processing of the data, especially by utilizing susceptibility data as an enhancing mask.
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Insights into the Epiphyseal Cartilage Origin and Subsequent Osseous Manifestation of Juvenile Osteochondritis Dissecans with a Modified Clinical MR Imaging Protocol: A Pilot Study
Jutta M. Ellermann,Casey P. Johnson,Luning Wang,Jeffrey A. Macalena,Bradley J. Nelson,Robert F. LaPrade +5 more
TL;DR: The modified MR imaging protocol allowed for identification of the epiphyseal cartilage origin and subsequent stages of ossification in JOCD and may better guide clinical management of the disease.
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Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis
TL;DR: Cartilage necrosis, characteristic of early OC, can be induced by interrupting the vascular supply to the distal femoral AECC in goat kids by utilizing magnetic resonance imaging (MRI) and adiabatic T1ρ relaxation time mapping to identify necrotic areas of cartilage.
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