Showing papers in "Journal of Orthopaedic Research in 2013"

TL;DR: Porous titanium scaffolds facilitate bone formation, which results in high mechanical integrity of the treated large bone defects, and reducing the strut size reduces the stiffness of the structure and may have a positive effect on bone formation.

TL;DR: Results show that a 6‐week gait retraining program can reduce the KAM and improve symptoms for individuals with medial compartment knee osteoarthritis and knee pain.

TL;DR: Increased level of pro‐inflammatory cytokines (IL‐6 and IL‐8) in the acute phase of inflammation which could be responsible for triggering cartilage catabolism is shown and it is suggested that prompt neutralization of IL‐ 6 andIL‐8 accumulations in synovial fluid could help prevent development of OA in ACL‐injured knees.

TL;DR: Experimental evidence is provided that mitochondrial‐derived ROS play a causal role in driving changes linked to aging‐related IDD and a potentially important role for radical scavengers in preventing IDD.

TL;DR: Findings support that diabetes induced by STZ can cause IDD by accelerating the apoptosis and senescence of NP cells excluding the overweight influence and suggest that the autophagy may be a response mechanism to the change ofNP cells in diabetic rats.

TL;DR: The serum COMP levels may be used as a diagnostic OA marker along with prognostic value in determining the patients at risk of rapidly progressing this debilitating joint disease.

TL;DR: Multivariable analysis demonstrated no significant correlations between the volume of material lost from the taper surfaces and either blood cobalt or chromium ions, or the presence of pseudotumor.

TL;DR: Overall, cartilage and meniscus catabolism was significantly more sensitive to IL‐1α thanIL‐1β at concentrations of 1 ng/ml or less, while few differences were observed between the two forms at 10 NG/ml.

TL;DR: It is suggested that SIRT1 can play a protective role by suppressing IL‐1β‐induced expressions of cartilage‐degrading enzymes partially through the modulation of the NF‐κB pathway.

TL;DR: In this article, the effect of surface finish and contact area associated with a single combination of materials of modular tapers was investigated in metal-on-metal (MoM) total hip replacement (THR).

TL;DR: It is demonstrated that the cobalt‐chrome head wears preferentially to the titanium stem taper, while samples with “axisymmetric” radial wear and a threaded imprint suggested that corrosion led to head subsidence onto the stem tapers with gradual rotation.

TL;DR: The stair climbing results indicate that problems still exist in the hip joint for activities requiring higher ranges of hip motion and suggest a basis for exploring future improvements for the treatment of FAI.

TL;DR: It is suggested that osteocytes lacking Cx43 are “primed” to respond to mechanical stimulation and that absence of Cx 43 in osteocytes unleashes bone formation, by a mechanism that might involve accumulation of β‐catenin.

TL;DR: Findings indicate that the mouse caudal disc model can be a powerful tool for investigating disc degeneration and therapy and the injection of therapeutics into the NP with a minimal needle size may limit damage due to the needle insertion.

TL;DR: Synovial MSCs injected into the knee adhered around the meniscal defect, and promoted meniscal regeneration in rabbits, and histological score was better in the MSC group than in the control group at 1, 3, 4, and 6 months.

TL;DR: The result showed that the volume of bone susceptible to yielding in the head and neck region is the lowest for inferior positions and increases as the lag screw is moved superiorly, which suggests that a TAD >25 mm cannot be considered to be an accurate predictor of lag screw cut‐out.

TL;DR: These kinematic and stability tests could not demonstrate enhanced mid‐range stability of the single‐radius TKA over the older multi‐radius implant, which suggests that mid-range instability may relate to unrecognized ligament laxity during surgery, rather than being inherent to a specific feature of implant design.

TL;DR: It is suggested that interplays between cell–matrix and cell–cell interactions contribute to hMSCs differentiation, and the promotion of osteogenic differentiation on hard matrix was shown to be mediated through the Ras pathway.

TL;DR: The NALP3 inflammasome is identified as a critical mediator of orthopedic wear‐induced osteolysis and as a viable therapeutic target for the treatment of periprosthetic osteolytic.

TL;DR: The results strongly suggest that BMP9 may effectively overcome noggin inhibition, which should at least in part contribute to B MP9's potent osteogenic capability in MSCs.

TL;DR: The present study suggests that anterior radial tear causes the highest risk for the development of total meniscal rupture, whereas partial meniscectomy increases the risk forThe development of OA in lateral tibial cartilage.

TL;DR: SSM described variations in femoral morphology that corresponded well with areas prone to damage that may facilitate objective characterization of cam FAI deformities and guide surgical resection of bone.

TL;DR: The results suggest that when total contact force may be changing, caution should be exercised when inferring changes in knee contact forces based on observed changes in external knee load and EMG measures.

TL;DR: The findings suggest that Dex treatment in clinics may cause a paradoxical effect on the injured tendons it is supposed to treat: by inducing non‐tenocyte differentiation of hTSCs, Dex treatment depletes the stem cell pool and leads to the formation of non‐tendinous tissues, which make tendon susceptible to rupture.

TL;DR: In this in vitro study, primary stability and stress shielding of a new cementless short stem implant was evaluated in comparison to a straight stem using nine pairs of human cadaver femurs to predict bone‐implant performance.

TL;DR: Using this systematic translational approach, “bio‐enhanced” ACL repair has been advanced to the point where it may become an option for future treatment of acute ACL injuries and the prevention of subsequent post‐traumatic osteoarthritis associated with this injury.

TL;DR: The data support the use of submicron‐sized electrospun fibers for engineering of oriented fibrous tissue mimetic, such as periosteum, for guided bone repair and reconstruction.

TL;DR: In this paper, the role of Smad3 in normal tendon development or tenocyte gene expression was investigated using mice deficient in Smad-3 (Smad3(-/-) ).

TL;DR: Phagocytosable larger/irregular shaped particles demonstrated the greatest lysosomal destabilization and inflammatory reactivity when compared on an equal dose basis (particles/cell) to smaller/spherical 1 µm particles in vitro.

TL;DR: This is the first study to estimate medial and lateral compartment contact forces in patients with acute ACL rupture using an approach which is sensitive to individual muscle activation patterns, and major finding was that joint loading was altered in the injured limb after acute ACL injury.