Book ChapterDOI
Hormonal Control of Gluconeogenesis
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Studies in the perfused liver indicate that only alanine, serine, proline, threonine, glutamine, asparagine, glutamate, aspartate, and arginine yield significant amounts of carbohydrate.Abstract:
Gluconeogenesis is the process by which glucose and glycogen are synthesized in the animal body from noncarbohydrate precursors. The liver and the kidney are the two organs which carry out gluconeogenesis and gluconeogenic substrates include lactate, pyruvate, glycerol, and the glucogenic amino acids. Although all the natural amino acids except leucine and lysine are potentially glucogenic by virtue of the fact that they yield pyruvate, oxalacetate, aketoglutarate, succinyl-CoA, or fumarate during their catabolism, studies in the perfused liver indicate that only alanine, serine, proline, threonine, glutamine, asparagine, glutamate, aspartate, and arginine yield significant amounts of carbohydrate (Ross, Hems, and Krebs, 1967).read more
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References
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Journal ArticleDOI
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Journal ArticleDOI
Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.
TL;DR: Leucine, isoleucaine, and valine appear responsible for the effects of plasma amino or isoleucine andValine together, also were able to inhibit protein degradation and promote synthesis and five times normal plasma concentrations of the amino acids had larger effects.
Journal ArticleDOI
Liver and kidney metabolism during prolonged starvation
TL;DR: This study quantifies the concentrations of circulating insulin, growth hormone, glucose, free fatty acids, glycerol, beta-hydroxybutyrate, acetoacetate, and alpha amino nitrogen in 11 obese subjects during prolonged starvation.
Journal ArticleDOI
Substrate Turnover during Prolonged Exercise in Man: SPLANCHNIC AND LEG METABOLISM OF GLUCOSE, FREE FATTY ACIDS, AND AMINO ACIDS
TL;DR: Blood glucose levels fall because hepatic glucose output fails to keep up with augmented glucose utilization by the exercising legs, and augmented secretion of glucagon may play an important role in the metabolic adaptation to prolonged exercise by its stimulatory influence on hepatic glycogenolysis and gluconeogenesis.