Patent
Human antibodies derived from immunized xenomice
TLDR
In this paper, a transgenic animal has been modified to produce antibodies in response to antigenic challenge, but whose endogenous loci have been disabled, and various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.Abstract:
Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.read more
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Transgenic mammals having human Ig loci including plural VH and VK regions and antibodies produced therefrom
TL;DR: In this paper, a transgenic non-human animal was engineered to contain human immunoglobulin gene loci, including plural variable (V H and Vκ) gene regions.
Patent
Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
Alan J. Korman,Mohan Srinivasan,Changyu Wang,Mark J. Selby,Bingliana Chen,Josephine M. Cardarelli +5 more
TL;DR: In this article, isolated monoclonal antibodies were used to detect PD-1 with high affinity and to treat various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies.
Patent
Albumin Fusion Proteins
TL;DR: The present invention encompasses albumin fusion proteins as discussed by the authors, as well as vectors containing these nucleic acids, host cells transformed with the nucleic acid vectors, and methods of making the fusion proteins of the invention.
Patent
Dual variable domain immunoglobulins and uses thereof
TL;DR: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Patent
Human monoclonal antibodies to epidermal growth factor receptor
TL;DR: In this paper, the authors provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r) and Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules.
References
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Patent
Transgenic non-human animals capable of producing heterologous antibodies
Nils Lonberg,Robert M. Kay +1 more
TL;DR: In this paper, a transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity are described.
Patent
Transgenic non-human animals for producing heterologous antibodies
Nils Lonberg,Robert M. Kay +1 more
TL;DR: In this paper, a transgenes containing sequences of unrearranged heterologous human immunoglobulin heavy chains are introduced into a non-human animal, thereby forming a transgenic animal capable of functionally rearranging transgenio-globulin sequences and producing a repertoire of antibodies.
Journal ArticleDOI
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
Kirk R. Thomas,Mario R. Capecchi +1 more
TL;DR: This work mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells and compared the gene-targeting efficiencies of two classes of neor-Hprt recombinant vectors.
Journal ArticleDOI
Single-chain antigen-binding proteins
Robert E. Bird,Karl D. Hardman,James W. Jacobson,Syd Johnson,Bennett M. Kaufman,Shwu Maan Lee,Timothy K. Lee,Sharon H. Pope,Gary S. Riordan,Marc Whitlow +9 more
TL;DR: Three single-chain antigen-binding proteins are novel recombinant polypeptides, composed of an antibody variable light-chain amino acid sequence tethered to a variable heavy-chain sequence (VH) by a designed peptide that links the carboxyl terminus of the VL sequence to the amino terminusof the VH sequence.
Patent
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
Nils Lonberg,Robert M. Kay +1 more
TL;DR: In this article, a transgenes containing sequences of unrearranged heterologous human immunoglobulin heavy chains are introduced into a non-human animal, thereby forming a transgenic animal capable of functionally rearranging transgenio-globulin sequences and producing a repertoire of antibodies.