Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axis
David W. Johnson,Heather J. Saunders,Bronwyn K. Brew,Anand N. Ganesan,Robert C. Baxter,Philip Poronnik,David I. Cook,Akos Z. Gyory,Michael Field,Carol A. Pollock +9 more
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TLDR
IGF-I, an analog that binds to the IGF-I receptor but not to IGFBPs, provided a less potent stimulus for PTC growth compared with IGF-i, indicating that cell-associated IGFBP-3 facilitates the action of IGF- I on PTC.About:
This article is published in Kidney International.The article was published on 1997-12-01 and is currently open access. It has received 54 citations till now. The article focuses on the topics: Growth factor & Sodium–hydrogen antiporter.read more
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The proximal tubule in the pathophysiology of the diabetic kidney
TL;DR: This review focuses on the proximal tubule in the early diabetic kidney, particularly on its exposure and response to high glucose levels, albuminuria, and other factors in the diabetic glomerular filtrate, the hyperreabsorption of glucose, and the unique molecular signature of the tubular growth phenotype.
Journal ArticleDOI
Erythropoietin protects against ischaemic acute renal injury
TL;DR: The results suggest that, in addition to its well-known erythropoietic effects, EPO inhibits apoptotic cell death, enhances tubular epithelial regeneration and promotes renal functional recovery in hypoxic or ischaemic acute renal injury.
Journal ArticleDOI
Renal Function in Diabetic Disease Models: The Tubular System in the Pathophysiology of the Diabetic Kidney
Volker Vallon,Scott C. Thomson +1 more
TL;DR: A pathophysiological concept that focuses on the tubular system to explain changes in the kidney, which states that early tubular growth and sodium-glucose cotransport enhance proximal tubule reabsorption and make the GFR supranormal through the physiology of tubuloglomerular feedback is outlined.
OtherDOI
Pathophysiology of the diabetic kidney.
Volker Vallon,Radko Komers +1 more
TL;DR: The pathophysiological changes that occur in the kidney in response to hyperglycemia are reviewed, including the cellular responses to high glucose and the responses in vascular, glomerular, podocyte, and tubular function.
Journal ArticleDOI
An energy-rich diet causes rumen papillae proliferation associated with more IGF type 1 receptors and increased plasma IGF-1 concentrations in young goats.
Zanming Shen,Hans-M. Seyfert,Berthold Löhrke,Falk Schneider,Rudi Zitnan,Arthur Chudy,Siegfried Kuhla,H.M. Hammon,J. W. Blum,Holger Martens,H. Hagemeister,Juergen Voigt +11 more
TL;DR: Dietary energy-dependent alterations of rumen morphology and function are accompanied by corresponding changes in systemic IGF-1 and ruminal IGF-2R and rumen papillary IGF type 1 receptors.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Book
Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems
TL;DR: Kinetics of Unireactant Enzymes.
Journal ArticleDOI
Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.
Robert C. Baxter,Janet L. Martin +1 more
TL;DR: Measurement of BP may provide a useful adjunct to IGF assays in growth disorders, and strong growth hormone-dependence of BP was seen; there was a 2.2-fold increase in active acromegaly and a 50-80% reduction in growth hormone deficiency.
Journal ArticleDOI
Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors.
TL;DR: Evidence that fibroblast-derived soluble factors play a crucial role in the control of epithelial morphogenesis is obtained and the involvement of diffusible paracrine factors in morphogenetic epithelial-mesenchymal interactions is demonstrated and a strategy for their molecular characterization is provided.
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