Journal ArticleDOI
Human sperm fertilizing potential in vitro is correlated with differential expression of a head-specific mannose-ligand receptor.
Susan Benoff,George W. Cooper,Ian R. Hurley,Barbara Napolitano,David L. Rosenfeld,Gerald M. Scholl,Avner Hershlag +6 more
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In this paper, the presence of D-mannose-ligand binding sites on the surface of heads of human spermatoza is associated with the ability of sperm to recognize and fertilize eggs in vitro.Citations
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Varicocele and male infertility: Part II: Pathophysiology of varicoceles in male infertility
TL;DR: The role of hyperthermia, testicular blood flow and venous pressure changes, reflux of renal/adrenal products, hormonal dysfunction, autoimmunity, defects in acrosome reaction, and oxidative stress, in the pathophysiology of varicocele will be discussed.
Journal ArticleDOI
Olfactory receptors are displayed on dog mature sperm cells.
TL;DR: It is demonstrated that a few dog genes representative of various subfamilies of olfactory receptors are expressed essentially in testis, with little or no expression in Olfactory mucosa, which is consistent with a role as sensor for unidentified chemicals possibly involved in the control of mammalian sperm maturation, migration, and/or fertilization.
Journal ArticleDOI
Recombinant human zona pellucida protein zp3 produced by chinese hamster ovary cells induces the human sperm acrosome reaction and promotes sperm-egg fusion
M. van Duin,J. E. M. Polman,I. T. M. De Breet,K. Van Ginneken,Hans Bunschoten,A. Grootenhuis,J.P. Brindle,R. J. Aitken +7 more
TL;DR: RecZP3 induced the sperm acrosome reaction and promoted fusion of human spermatozoa with zona-free hamster oocytes, indicating that the recombinant protein is biologically active, and provides an attractive tool for studying the initial stage of the human fertilization process.
Journal ArticleDOI
Cadmium concentrations in blood and seminal plasma: correlations with sperm number and motility in three male populations (infertility patients, artificial insemination donors, and unselected volunteers).
Susan Benoff,Susan Benoff,Susan Benoff,Russ Hauser,Joel L. Marmar,Ian R. Hurley,Barbara Napolitano,Grace M. Centola +7 more
TL;DR: Human and rat study results are consistent with the hypothesis that environmental cadmium exposures may contribute significantly to reduced human male sperm concentration and sperm motility and validate the human findings in an animal model.
References
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The Physiology of Reproduction
Ernst Knobil,J. D. Neill +1 more
TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
Journal ArticleDOI
Predictive value of abnormal sperm morphology in in vitro fertilization
Thinus F. Kruger,Anibal A. Acosta,Anibal A. Acosta,K.F. Simmons,K.F. Simmons,R.J. Swanson,R.J. Swanson,J.F. Matta,J.F. Matta,Sergio Oehninger,Sergio Oehninger +10 more
TL;DR: By evaluating sperm morphology with the proposed strict criteria, its predictive value in in vitro fertilization is enhanced.
Journal ArticleDOI
Two simple methods for detecting acrosome‐reacted human sperm
TL;DR: Two methods for detecting acrosome reactions of human sperm at the light microscopic level are described, rapid, give similar results, and detect an increase in acrosomes reactions following exposure to the ionophore A23187.
Journal ArticleDOI
Induction of acrosome reactions by the human zona pellucida.
TL;DR: It is concluded that the human zona pellucida, or material intimately associated with it, can induce acrosome reactions in human sperm.
Journal ArticleDOI
Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction.
TL;DR: It is suggested that the aggregation of sperm molecules recognized by ZP3 glycopeptides or by TPA-treated ZP is sufficient to trigger the events that occur during acrosomal exocytosis.