Journal ArticleDOI
Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol)
TLDR
This paper reports the hydrolytic degradation and protein release studies for a series of newly synthesized thermogelling tri-component multi-block poly(ether ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] (PHB), poly(propylene glycol) (PPG), and poly(ethylene glycol).About:
This article is published in Biomaterials.The article was published on 2007-10-01. It has received 196 citations till now. The article focuses on the topics: Ethylene glycol & Self-healing hydrogels.read more
Citations
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Journal ArticleDOI
Hydrogels in drug delivery: progress and challenges
Todd Hoare,Daniel S. Kohane +1 more
TL;DR: Recent progress in overcoming challenges with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs fromhydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches is discussed.
Journal ArticleDOI
Injectable hydrogels as unique biomedical materials
Lin Yu,Jiandong Ding +1 more
TL;DR: This tutorial review summarizes and comments on this soft matter, especially thermogelling poly(ethylene glycol)-(biodegradable polyester) block copolymers, including both physical gels and chemical gels.
Journal ArticleDOI
Thermoresponsive hydrogels in biomedical applications.
Leda Klouda,Antonios G. Mikos +1 more
TL;DR: The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change and focuses mainly on hydrogels based on natural polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.
Journal ArticleDOI
Hydrogels for protein delivery.
Journal ArticleDOI
Current development of biodegradable polymeric materials for biomedical applications
TL;DR: This review outlines the current development of biodegradable natural and synthetic polymeric materials for various biomedical applications, including tissue engineering, temporary implants, wound healing, and drug delivery.
References
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Journal ArticleDOI
Biodegradable block copolymers as injectable drug-delivery systems
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.
Journal ArticleDOI
PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release.
TL;DR: In this article, a chitosan-based, injectable thermogel was prepared by grafting an appropriate amount of polyethylene glycol (PEG) onto the chitosa backbone and studied for drug release in vitro using bovine serum albumin (BSA) as a model protein.
Journal ArticleDOI
Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers
TL;DR: Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37 degrees C aqueous environment.
Journal ArticleDOI
In situ forming degradable networks and their application in tissue engineering and drug delivery.
Kristi S. Anseth,Andrew T. Metters,Stephanie J. Bryant,Penny J. Martens,Jennifer H. Elisseeff,Christopher N. Bowman +5 more
TL;DR: A degradation mechanism assuming pseudo first-order hydrolysis kinetics and accounting for the structure of the crosslinked networks successfully predicted the experimentally observed trends in these properties with degradation, and the application of these macromers as in situ forming hydrogel constructs for cartilage tissue engineering is demonstrated.