Journal ArticleDOI
Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.
Stefania D'Angelo,Diego Ingrosso,Valentina Migliardi,Alvara Sorrentino,Giovanna Donnarumma,Adone Baroni,Lucia Masella,Maria Antonietta Tufano,Marcello Zappia,Patrizia Galletti +9 more
TLDR
In this paper, the effects of hydroxytyrosol (DOPET), the major antioxidant compound present in olive oil, on UVA-induced cell damages were investigated, using a human melanoma cell line (M14) as a model system.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2005-04-01. It has received 156 citations till now. The article focuses on the topics: Hydroxytyrosol & Lipid peroxidation.read more
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Journal ArticleDOI
Hydroxytyrosol: from laboratory investigations to future clinical trials
Sergio Granados-Principal,José L. Quiles,Cesar L. Ramirez-Tortosa,Pedro Sánchez-Rovira,M. Carmen Ramirez-Tortosa +4 more
TL;DR: This review summarizes the existing knowledge concerning the chemistry, pharmacokinetics, and toxicology of hydroxytyrosol, a minor compound of virgin olive oil, as well as this compound's importance for health and main findings in terms of its beneficial effects in cardiovascular disease and cancer are emphasized.
Journal ArticleDOI
Comparison of the concentrations of phenolic compounds in olive oils and other plant oils: correlation with antimicrobial activity.
TL;DR: Results indicate that not all oils classified as "olive oil" had similar bactericidal effects and that this bioactivity depended on their content of certain phenolic compounds.
Journal ArticleDOI
Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells.
Vlassios Goulas,Vassiliki Exarchou,Anastassios N. Troganis,Eleni Psomiadou,Theodoros Fotsis,Evangelos Briasoulis,Ioannis P. Gerothanassis +6 more
TL;DR: Olive-leaf crude extracts were found to inhibit cell proliferation of human breast adenocarcinoma, human urinary bladder carcinoma and bovine brain capillary endothelial and the dominant compound was oleuropein; phenols and flavonoids were also identified.
Journal ArticleDOI
Hydroxytyrosol: Bioavailability, toxicity, and clinical applications.
María Robles-Almazan,Mario Pulido-Moran,Jorge Moreno-Fernandez,Cesar L. Ramirez-Tortosa,Carmen Rodriguez-Garcia,José L. Quiles,MCarmen Ramirez-Tortosa +6 more
TL;DR: The vast range of information about hydroxytyrosol is described, focusing on its involvement in biological mechanisms and modulation effects on different pathologies, to highlight the role of hydroxyTYrosol as a nutraceutical and as a potential therapeutic agent.
Journal ArticleDOI
In vitro activity of olive oil polyphenols against Helicobacter pylori.
TL;DR: Virgin olive oil contains phenolic compounds that can diffuse from the oil into the gastric juice and be stable for hours in this acidic environment, and these substances exerted a strong bactericidal activity against eight strains of H. pylori, three of them resistant to some antibiotics.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Book ChapterDOI
Microsomal lipid peroxidation.
John A. Buege,Steven D. Aust +1 more
TL;DR: This chapter discusses microsomal lipid peroxidation, a complex process known to occur in both plants and animals that involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids.