Hyperhomocysteinemia and Endothelial Dysfunction.
Reads0
Chats0
TLDR
Six mechanisms have been suggested explaining HHcy-induced endothelial dysfunction and the goal of this review is to elaborate these mechanisms and to discuss biological and molecular events related to HHCy-induced ED.Abstract:
Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular diseases. Endothelial dysfunction (ED) is the earliest indicator of atherosclerosis and vascular diseases. We and others have shown that HHcy induced ED in human and in animal models of HHcy induced by either high-methionine load or genetic deficiency. Six mechanisms have been suggested explaining HHcy-induced ED. These include 1) nitric oxide inhibition, 2) prostanoids regulation, 3) endothelium-derived hyperpolarizing factors suppression, 4) angiotensin II receptor-1 activation, 5) endothelin-1 induction, and 6) oxidative stress. The goal of this review is to elaborate these mechanisms and to discuss biological and molecular events related to HHcy-induced ED.read more
Citations
More filters
Journal ArticleDOI
The Effect of Physical Activity on Cardiovascular Markers
TL;DR: In this paper, the authors investigated the effect of physical activity on cardiovascular markers (C-reactive protein (CRP) and Homocysteine (HCY)), and conducted an optimal compilation to present better information from previous studies.
Journal ArticleDOI
Multiparametric Assessment of Vascular Function and Atherosclerosis in Patients with Autoimmune Gastritis: A Comparative Study
Mustafa Yakut,Yusuf Üstün,Sim Kutlay,Aydan Ongun,Gökhan Kabaçam,Recai Boynueğri,Irfan Soykan +6 more
TL;DR: Patients with autoimmune gastritis may have an increased risk for the development of early atherosclerosis and as early preventive treatment for accelerated Atherosclerosis is available, it is important to detect those patients with autoimmune Gastritis who would benefit from such treatment.
Book ChapterDOI
Homocysteinemia and Viral Infection with Special Emphasis on COVID-19
TL;DR: In this article , the critical role of homocysteine as a key factor of coagulation in prognosis of severe acute respiratory syndrome coronavirus disease 2019 (COVID-19) infected patients was discussed.
Journal ArticleDOI
The significance of homocysteine in patients with hypertension
Jerzy Głuszek,Teresa Kosicka +1 more
Journal ArticleDOI
Choc cardiogénique dû à une thrombose spontanée néonatale de l’aorte abdominale
TL;DR: The observation of a 10-day-old term infant showed a large abdominal aortic thrombosis revealed by cardiogenic shock induced by systemic arterial hypertension, which was fast following anticoagulant and antihypertensive therapy.
References
More filters
Journal ArticleDOI
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
TL;DR: Higher folic acid intake by reducing tHcy levels promises to prevent arteriosclerotic vascular disease and under different assumptions, 13,500 to 50,000 CAD deaths annually could be avoided.
Journal Article
Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.
TL;DR: Since the enzymatic abnormalities in both disorders share certain metabolic consequences, the conclusion has been reached that an elevated concentration of homocysteine, homocystine, or a derivative of hornocysteines is the common factor leading to arterial damage.
Journal ArticleDOI
Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.
Jonathan S. Stamler,John A. Osborne,Omar Jaraki,LeRoy E. Rabbani,Mark E. Mullins,David J. Singel,Joseph Loscalzo +6 more
TL;DR: These results suggest that the normal endothelium modulates the potential, adverse effects of homocysteine by releasing EDRF and forming the adduct S-NO-homocysteines, a potent antiplatelet agent and vasodilator.
Journal ArticleDOI
EDHF: bringing the concepts together.
TL;DR: Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization and the main concepts are considered in detail in this review.
Journal ArticleDOI
Homocysteine Impairs the Nitric Oxide Synthase Pathway Role of Asymmetric Dimethylarginine
Markus Stühlinger,Philip S. Tsao,Jeng Horng Her,Masumi Kimoto,Robert F. Balint,John P. Cooke +5 more
TL;DR: Homocysteine post-translationally inhibits DDAH enzyme activity, causing ADMA to accumulate and inhibit nitric oxide synthesis, which may explain the known effect of homocysteines to impair endothelium-mediated nitricoxide–dependent vasodilatation.