Journal ArticleDOI
EDHF: bringing the concepts together.
Reads0
Chats0
TLDR
Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization and the main concepts are considered in detail in this review.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2002-08-01. It has received 845 citations till now. The article focuses on the topics: Endothelium-derived hyperpolarizing factor & Hyperpolarization (biology).read more
Citations
More filters
Journal ArticleDOI
Endothelial Function and Dysfunction Testing and Clinical Relevance
TL;DR: Current understanding of endothelial biology in health and disease, the strengths and weaknesses of current testing strategies, and their potential applications in clinical research and patient care are summarized.
Journal ArticleDOI
Endothelial dysfunction and vascular disease
TL;DR: The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances, which are reduced in the course of vascular disease and selectively loose the pertussis toxin‐sensitive pathway for NO release which favours vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis.
Journal ArticleDOI
The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function.
TL;DR: The mechanisms of FMD depend on the nature of the shear stress stimulus (stimulus response specificity), an update to the current guidelines for FMD assessment is provided, and the issues that surround the clinical utility of measuring both NO‐ and non‐NO‐mediated FMD are summarized.
Journal ArticleDOI
Vascular protection by dietary polyphenols.
Jean-Claude Stoclet,Thierry Chataigneau,Mamadou N'Diaye,Min-Ho Oak,Jasser El Bedoui,Marta Chataigneau,Valérie B. Schini-Kerth +6 more
TL;DR: The current evidence suggests that all these mechanisms are triggered by polyphenols with specific structures, although the structural requirements may be different from one effect to the other, and that they all contribute to the vasoprotective,Anti-angiogenic, anti-atherogenic, vasorelaxant and anti-hypertensive effects of acute or chronic administration of plant polyphenol found in vivo in animals and in patients.
Journal ArticleDOI
Endothelium-Derived Hyperpolarizing Factor Where Are We Now?
Michel Félétou,Paul M. Vanhoutte +1 more
TL;DR: The endothelium controls vascular tone not only by releasing nitric oxide and prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth muscle cells, which can be evoked by direct electrical coupling through myo-endothelial junctions and/or the accumulation of potassium ions in the intercellular space.
References
More filters
Journal ArticleDOI
Physiological roles and properties of potassium channels in arterial smooth muscle
Mark T. Nelson,J. M. Quayle +1 more
TL;DR: The main conclusions of this review are: 1) regulation of arterial smooth muscle membrane potential through activation or inhibition of K+ channel activity provides an important mechanism to dilate or constrict arteries; 2) KV, KCa, KIR, and KATP channels serve unique functions in the regulation of artery membrane potential
Journal ArticleDOI
Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors
TL;DR: Data support the hypothesis that the EETs are EDHFs, which causes endothelium-dependent relaxations of coronary arteries through its metabolism to epoxyeicosatrienoic acids by cytochrome P450 by boosting the open-state probability of a Ca2+-activated K+ channel in coronary smooth muscle cells.
Journal ArticleDOI
Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone
TL;DR: It is shown that voltage-dependent Ca channels in the steady state can be open and very sensitive to membrane potential changes in a range that occurs in resistance arteries with tone.
Journal ArticleDOI
K+ is an endothelium-derived hyperpolarizing factor in rat arteries
TL;DR: The results show that fluctuations in K+ levels originating within the blood vessel itself are important in regulating mammalian blood pressure and flow.
Journal ArticleDOI
Cytochrome P450 2C is an EDHF synthase in coronary arteries
Beate Fisslthaler,Rüdiger Popp,Ladislau Kiss,Michael Potente,David R. Harder,Ingrid Fleming,Rudi Busse +6 more
TL;DR: It is shown that the induction of cytochrome P450 (CYP) 2C8/34 in native porcine coronary artery endothelial cells by β-naphthoflavone enhances the formation of 11,12-epoxyeicosatrienoic acid, as well as EDHF-mediated hyperpolarization and relaxation.