Hypophosphatasia associated with calcium pyrophosphate dihydrate deposits in cartilage
John D O'Duffy,John D O'Duffy +1 more
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TLDR
A 51-year-old woman with hypophosphatasia had diffuse bone pain and widespread calcification in articular cartilage and analysis of cartilage from the pubic symphysis revealed calcium pyrophosphate crystals.Abstract:
A 51-year-old woman with hypophosphatasia had diffuse bone pain and widespread calcification in articular cartilage. Attacks of monarthritis had occurred for 27 years. Analysis of cartilage from the pubic symphysis revealed calcium pyrophosphate crystals.read more
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Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization.
TL;DR: How ALP acts was clarified by the discoveries that several phosphocompound substrates for tissue-nonspecific ALP (TNSALP) accumulate endogenously in this inborn error of metabolism.
Journal ArticleDOI
Diseases associated with calcium pyrophosphate deposition disease.
TL;DR: There is good evidence to associate hypophosphatasia, hypomagnesemia, and hyperparathyroidism with chondrocalcinosis and acute attacks of "pseudogout" and the biochemical mechanisms that may produce these various associations are discussed.
Journal ArticleDOI
Inorganic pyrophosphate in plasma, urine, and synovial fluid of patients with pyrophosphate arthropathy (chondrocalcinosis or pseudogout)
Roslin Russell,Roslin Russell,S Bisaz,S Bisaz,H. Fleisch,H. Fleisch,H.L.F Currey,H.M Rubinstein,A.A Dietz,I Boussina,A Micheli,G. H. Fallet +11 more
TL;DR: The concentration of inorganic pyrophosphate (I.P.P.) has been determined in the plasma, urine, and synovial fluid of patients with pyroph phosphate arthropathy (chondrocalcinosis articularis or pseudogout) and metabolism in pyroph phosphate arthropathetic seems to be a local rather than generalised phenomenon.
Journal ArticleDOI
Clinical spectrum of hypophosphatasia diagnosed in adults
Kathryn E. Berkseth,Peter J. Tebben,Matthew T. Drake,Theresa E. Hefferan,Donna E Jewison,Robert A. Wermers +5 more
TL;DR: It is suggested that adult HPP demonstrates a wide spectrum of clinical manifestations including musculoskeletal pain, fractures, chondrocalcinosis and dental anomalies with some overlap in laboratory characteristics in relationship to disease severity.
Journal ArticleDOI
Musculoskeletal manifestations of osteomalacia: report of 26 cases and literature review.
TL;DR: OM is usually neglected when compared with other metabolic bone diseases and may present with a variety of clinical and radiographic manifestations mimicking other musculoskeletal disorders.
References
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The Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The Pseudogout Syndrome: I. Clinical Aspects
TL;DR: In this article, the authors examined over 200 consecutive specimens of synovial fluid with phase contrast and polarized light microscopy and obtained a collection of fluids from seven patients from seven different patients.
Journal Article
The Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The "Pseudogout Syndrome"
TL;DR: Excerpt In the course of examining over 200 consecutive specimens of synovial fluid with phase contrast and polarized light microscopy, a collection of fluids from seven patients was obtained and it was found that some of the fluids obtained belonged to the central nervous system.
Journal ArticleDOI
A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow.
TL;DR: Alkaline phosphatase activity was found only in neutrophilic granulocytes and was localized exclusively in the cytoplasm of these cells.
Journal ArticleDOI
Isolation from urine of pyrophosphate, a calcification inhibitor.
Herbert Fleisch,Sylvia Bisaz +1 more
TL;DR: The minimum value of the product, Ca X P, necessary for calcium phosphate precipitation to occur, was determined in vitro and the addition of 2.2% urine to the solutions raised the mean product from 53 to 105 (mg/100 ml), which shows that the urine contains inhibitors to hydroxyapatite precipitation.